Elavl3 MGI Mouse Gene Detail - MGI:109157 - ELAV like RNA binding protein 3

Symbol

Elavl3
Name

ELAV like RNA binding protein 3
Synonyms

2600009P04Rik, Huc, mHuC

Feature Type

protein coding gene
IDs

MGI:109157
NCBI Gene: 15571
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr9:21926301-21963319 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 8.07 cM
Mapping Data

2 experiments

SNPs within 2kb

785 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109157	protein coding gene	Chr9:21926301-21963442 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0034474	protein coding gene	Chr9:19292218-19338943 (-)
A/J	MGP_AJ_G0034452	protein coding gene	Chr9:18919096-18955059 (-)
AKR/J	MGP_AKRJ_G0034378	protein coding gene	Chr9:19285293-19321722 (-)
BALB/cJ	MGP_BALBcJ_G0034443	protein coding gene	Chr9:18801219-18837944 (-)
C3H/HeJ	MGP_C3HHeJ_G0034155	protein coding gene	Chr9:19589122-19629653 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0034964	protein coding gene	Chr9:20050161-20110259 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031894	protein coding gene	Chr9:18019695-18057100 (-)
CAST/EiJ	MGP_CASTEiJ_G0033478	protein coding gene	Chr9:19425260-19464974 (-)
CBA/J	MGP_CBAJ_G0034128	protein coding gene	Chr9:20843360-20885692 (-)
DBA/2J	MGP_DBA2J_G0034286	protein coding gene	Chr9:18883291-18920408 (-)
FVB/NJ	MGP_FVBNJ_G0034229	protein coding gene	Chr9:18433086-18470600 (-)
LP/J	MGP_LPJ_G0034372	protein coding gene	Chr9:19443580-19497017 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034273	protein coding gene	Chr9:22398705-22435663 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034984	protein coding gene	Chr9:19250836-19290007 (-)
PWK/PhJ	MGP_PWKPhJ_G0033183	protein coding gene	Chr9:18889670-18927472 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033017	protein coding gene	Chr9:19295134-19322591 (-)
WSB/EiJ	MGP_WSBEiJ_G0033593	protein coding gene	Chr9:18992481-19029544 (-)

Human Ortholog

ELAVL3, ELAV like RNA binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ELAVL3, ELAV like RNA binding protein 3
Synonyms

HUC, HUCL, PLE21
Links

HGNC:3314

NCBI Gene ID: 1995

neXtProt AC: NX_Q14576

UniProt: Q14576
Chr Location

19p13.2; chr19:11451326-11481046 (-) GRCh38

MGI Vertebrate Homology

Elavl3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ELAVL3
Gene Tree

Elavl3

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Phenotype Summary

7 phenotypes from 1 allele in 3 genetic backgrounds
2 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

28 strains or lines available

Mice homozygous for a knock-out allele exhibit strain-specific preweaning lethality, abnormal cortical hypersynchronization and non-convulsive electropgraphic seizure. Mice heterozygous for the allele exhibit abnormal brain wave pattern and spike wave discharge.

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

855
Tissues

84
cDNA Data

15
Literature Summary

141

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase elavl3

ZFIN elavl3

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All Sequences

49
RefSeq

8
UniProt

3
CCDS

CCDS52741.1

Ensembl

ENSMUSG00000003410 (Evidence)
NCBI Gene

15571

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003410	Ensembl Gene Model \| MGI Sequence Detail	37019	C57BL/6J	± kb
transcript	ENSMUST00000003501	Ensembl \| MGI Sequence Detail	5014	Not Applicable
polypeptide	ENSMUSP00000003501	Ensembl \| MGI Sequence Detail	367	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007018 ELAV-like protein 3

(term hierarchy)
PDB

1D8Z, 1D9A, 1FNX
InterPro Domains

IPR034915 HuC, RNA recognition motif 3

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR002343 Paraneoplastic encephalomyelitis antigen

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR003954 RNA recognition motif domain, eukaryote

IPR006548 Splicing factor ELAV/Hu

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All nucleic 19

Genomic 1

cDNA 17

Primer pair 1

Microarray probesets 7

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MGD-MRK-38201, MGI:1913822

Summaries

All 175

Developmental Gene Expression 141

Gene Ontology 3

Phenotypes 9
Earliest

J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
Latest

J:348704 Vong KI, et al., Risk of meningomyelocele mediated by the common 22q11.2 deletion. Science. 2024 May 3;384(6695):584-590

TSS for Elavl3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr88449	Chr9:21963317-21963322 (-)	-1 bp
Tssr88448	Chr9:21963259-21963279 (-)	50 bp
Tssr88447	Chr9:21957729-21957733 (-)	5,588 bp
Tssr88446	Chr9:21936030-21936062 (-)	27,273 bp
Tssr88445	Chr9:21935716-21935719 (-)	27,601 bp
Tssr88444	Chr9:21933582-21933623 (-)	29,716 bp
Tssr88443	Chr9:21929970-21929981 (-)	33,343 bp
Tssr88442	Chr9:21929560-21929564 (-)	33,757 bp
Tssr88441	Chr9:21929178-21929193 (-)	34,133 bp
Tssr88440	Chr9:21928996-21929030 (-)	34,306 bp
Tssr88439	Chr9:21927728-21927747 (-)	35,581 bp
Tssr88438	Chr9:21927703-21927715 (-)	35,610 bp
Tssr88437	Chr9:21926586-21926600 (-)	36,726 bp
Tssr88436	Chr9:21926552-21926580 (-)	36,753 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24