Grk5 MGI Mouse Gene Detail - MGI:109161 - G protein-coupled receptor kinase 5

Symbol

Grk5
Name

G protein-coupled receptor kinase 5
Synonyms

Gprk5

Feature Type

protein coding gene
IDs

MGI:109161
NCBI Gene: 14773
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr19:60878187-61084406 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 56.52 cM
Mapping Data

2 experiments

SNPs within 2kb

3627 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109161	protein coding gene	Chr19:60877995-61084406 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025299	protein coding gene	Chr19:61503875-61699661 (+)
A/J	MGP_AJ_G0025275	protein coding gene	Chr19:58497702-58698974 (+)
AKR/J	MGP_AKRJ_G0025244	protein coding gene	Chr19:60328936-60527248 (+)
BALB/cJ	MGP_BALBcJ_G0025270	protein coding gene	Chr19:58579357-58774560 (+)
C3H/HeJ	MGP_C3HHeJ_G0025030	protein coding gene	Chr19:60566544-60767534 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025713	protein coding gene	Chr19:62957619-63161758 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023125	protein coding gene	Chr19:57319137-57514649 (+)
CAST/EiJ	MGP_CASTEiJ_G0024495	protein coding gene	Chr19:60672457-60880323 (+)
CBA/J	MGP_CBAJ_G0025010	protein coding gene	Chr19:66021967-66238828 (+)
DBA/2J	MGP_DBA2J_G0025142	protein coding gene	Chr19:58283380-58475500 (+)
FVB/NJ	MGP_FVBNJ_G0025103	protein coding gene	Chr19:57950754-58143662 (+)
LP/J	MGP_LPJ_G0025228	protein coding gene	Chr19:61338201-61531309 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025136	protein coding gene	Chr19:65217517-65427327 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025771	protein coding gene	Chr19:60564834-60768550 (+)
PWK/PhJ	MGP_PWKPhJ_G0024243	protein coding gene	Chr19:58224370-58421074 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024046	protein coding gene	Chr19:59215239-59437603 (+)
WSB/EiJ	MGP_WSBEiJ_G0024565	protein coding gene	Chr19:60676281-60879216 (+)

Human Ortholog

GRK5, G protein-coupled receptor kinase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRK5, G protein-coupled receptor kinase 5
Synonyms

FP2025, GPRK5
Links

HGNC:4544

NCBI Gene ID: 2869

neXtProt AC: NX_P34947

UniProt: P34947
Chr Location

10q26.11; chr10:119207571-119459745 (+) GRCh38

MGI Vertebrate Homology

Grk5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GRK5
Gene Tree

Grk5

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Phenotype Summary

15 phenotypes from 4 alleles in 6 genetic backgrounds
41 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Endonuclease-mediated

4
Gene trapped

1
Targeted

9
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in a decrease in thermal pain sensation. Mice homozygous for a knock-out allele exhibit decreased response of heart to induced stress.

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All GO Annotations

36
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

940
Tissues

120
cDNA Data

10
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase LOC550070

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All Sequences

51
RefSeq

10
UniProt

3
CCDS

CCDS29945.1

Ensembl

ENSMUSG00000003228 (Evidence)
NCBI Gene

14773

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003228	Ensembl Gene Model \| MGI Sequence Detail	206220	C57BL/6J	± kb
transcript	ENSMUST00000003313	Ensembl \| MGI Sequence Detail	6580	Not Applicable
polypeptide	ENSMUSP00000003313	Ensembl \| MGI Sequence Detail	590	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008259 G protein-coupled receptor kinase 5

(term hierarchy)
EC

2.7.11.-, 2.7.11.16
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR000239 GPCR kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR044926 RGS, subdomain 2

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All nucleic 13

cDNA 10

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-38205

Summaries

All 79

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 41
Earliest

J:36567 Jaber M, et al., Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12974-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Grk5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr5576	Chr19:60878727-60878737 (+)	545 bp
Tssr157367	Chr19:60878801-60878830 (+)	629 bp
Tssr157368	Chr19:60884647-60884650 (+)	6,462 bp
Tssr157369	Chr19:61039330-61039332 (+)	161,144 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24