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Fat1 Gene Detail
Summary
  • Symbol
    Fat1
  • Name
    FAT atypical cadherin 1
  • Synonyms
    2310038E12Rik, Fath, mFat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109168
    NCBI Gene: 14107
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:45388484-45505294 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 24.81 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3330 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109168
 protein coding gene Chr8:45386137-45505294 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033570
 protein coding gene Chr8:43951923-44073241 (+)
A/J MGP_AJ_G0033552
 protein coding gene Chr8:42273121-42389824 (+)
AKR/J MGP_AKRJ_G0033477
 protein coding gene Chr8:43501954-43619989 (+)
BALB/cJ MGP_BALBcJ_G0033549
 protein coding gene Chr8:42435435-42552407 (+)
C3H/HeJ MGP_C3HHeJ_G0033258
 protein coding gene Chr8:44016949-44135958 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034065
 protein coding gene Chr8:45619343-45745837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031014
 protein coding gene Chr8:38562949-38682755 (+)
CAST/EiJ MGP_CASTEiJ_G0032584
 protein coding gene Chr8:43441837-43563340 (+)
CBA/J MGP_CBAJ_G0033237
 protein coding gene Chr8:47468933-47588415 (+)
DBA/2J MGP_DBA2J_G0033390
 protein coding gene Chr8:42085473-42203425 (+)
FVB/NJ MGP_FVBNJ_G0033331
 protein coding gene Chr8:41583572-41703471 (+)
LP/J MGP_LPJ_G0033478
 protein coding gene Chr8:43980139-44098837 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033376
 protein coding gene Chr8:47563797-47683148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034083
 protein coding gene Chr8:43662280-43785303 (+)
PWK/PhJ MGP_PWKPhJ_G0032292
 protein coding gene Chr8:41607940-41727008 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032128
 protein coding gene Chr8:42828003-42949908 (+)
WSB/EiJ MGP_WSBEiJ_G0032700
 protein coding gene Chr8:43918281-44037527 (+)



Homology
more
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
  • Synonyms
    CDHF7, CDHR8, FAT, hFat1, ME5
  • Links
    NCBI Gene ID: 2195
    neXtProt AC: NX_Q14517
    UniProt: Q14517

  • Chr Location
    4q35.2; chr4:186587794-186726722 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Fat1 mouse models; 5 with human FAT1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 6 alleles in 6 genetic backgrounds
    13 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner earpatterning and kidney defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    81
  • cDNA Data
    247
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000070047 Ensembl Gene Model | MGI Sequence Detail 116811 C57BL/6J ±  kb
    transcript ENSMUST00000215588 Ensembl | MGI Sequence Detail 13938 Not Applicable  
    polypeptide ENSMUSP00000149194 Ensembl | MGI Sequence Detail 4645 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 255
      Genomic 3
      cDNA 247
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38212, MGI:1924002, MGI:2142710
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 15
      Diseases 2
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
    • Latest
      J:340632 Hernandez J, et al., n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. Int J Mol Sci. 2023 Aug 31;24(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory