Cd59a MGI Mouse Gene Detail - MGI:109177

Symbol

Cd59a
Name

CD59a antigen
Synonyms

Cd59, protectin

Feature Type

protein coding gene
IDs

MGI:109177
NCBI Gene: 12509
Alliance

gene page
Transcription Start Sites

5 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr2:103926146-103945699 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 54.53 cM, cytoband E2-E4
Mapping Data

8 experiments

SNPs within 2kb

696 from dbSNP Build 142
Strain Annotations

16
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109177	protein coding gene	Chr2:103926146-103945755 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026213	protein coding gene	Chr2:106110970-106174783 (+)
A/J	MGP_AJ_G0026175	protein coding gene	Chr2:101724938-101755831 (+)
AKR/J	MGP_AKRJ_G0026154	protein coding gene	Chr2:104493028-104523513 (+)
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0025935	protein coding gene	Chr2:104830107-104848380 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026635	protein coding gene	Chr2:109664089-109697631 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0025399	protein coding gene	Chr2:105315624-105321506 (+)
CBA/J	MGP_CBAJ_G0025912	protein coding gene	Chr2:113403731-113422128 (+)
DBA/2J	MGP_DBA2J_G0026050	protein coding gene	Chr2:101294472-101321841 (+)
FVB/NJ	MGP_FVBNJ_G0026012	protein coding gene	Chr2:100282369-100303757 (+)
LP/J	MGP_LPJ_G0026153	protein coding gene	Chr2:106253251-106277003 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026037	protein coding gene	Chr2:117296057-117325532 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026689	protein coding gene	Chr2:104716222-104748234 (+)
PWK/PhJ	MGP_PWKPhJ_G0025134	protein coding gene	Chr2:100813016-100845529 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024934	protein coding gene	Chr2:103913741-103931205 (+)
WSB/EiJ	MGP_WSBEiJ_G0025464	protein coding gene	Chr2:105395445-105427159 (+)

Human Ortholog

CD59, CD59 molecule (CD59 blood group)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD59, CD59 molecule (CD59 blood group)
Synonyms

16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
Links

HGNC:1689

NCBI Gene ID: 966

neXtProt AC: NX_P13987

UniProt: P13987
Chr Location

11p13; chr11:33703010-33736479 (-) GRCh38

MGI Vertebrate Homology

Cd59a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CD59
Gene Tree

Cd59a

Diseases

2 with human CD59 associations

				Human Disease	Mouse Models
				colorectal carcinoma IDs colorectal carcinoma DOID:0080199 EFO:1001951 MESH:D015179 NCI:C2955 UMLS_CUI:C0009402
				ovarian cancer IDs ovarian cancer DOID:2394 DOID:0060070 DOID:2144 DOID:9595 ICD10CM:C56 ICD9CM:183.0 MESH:D010051 NCI:C4984 NCI:C7431 OMIM:167000 OMIM:607893 ORDO:213500 ORDO:213517 UMLS_CUI:C0919267 UMLS_CUI:C1140680 UMLS_CUI:C1299247

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

32 phenotypes from 2 alleles in 6 genetic backgrounds
12 phenotypes from multigenic genotypes
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

40
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

32
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Cd59a
Incidental Mutations

APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal complement pathway, abnormal response to injury, altered susceptibility to viral infection, and abnormal CD4+ T cell morphology and physiology.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

897
Tissues

48
cDNA Data

82
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cd59

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All Sequences

50
RefSeq

10
UniProt

2
CCDS

CCDS16487.1

Ensembl

ENSMUSG00000032679 (Evidence)
NCBI Gene

12509

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032679	Ensembl Gene Model \| MGI Sequence Detail	19554	C57BL/6J	± kb
transcript	ENSMUST00000168176	Ensembl \| MGI Sequence Detail	1806	Not Applicable
polypeptide	ENSMUSP00000132774	Ensembl \| MGI Sequence Detail	123	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001999 CD59A glycoprotein

(term hierarchy)
InterPro Domains

IPR016054 Ly-6 antigen/uPA receptor-like

IPR045860 Snake toxin-like superfamily
GlyGen

O55186 2 sites

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All nucleic 93

Genomic 1

cDNA 83

Primer pair 9

Microarray probesets 4

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MGD-MRK-38221, MGI:2138824

Summaries

All 96

Developmental Gene Expression 9

Gene Ontology 8

Phenotypes 52
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:270774 Modinger Y, et al., Reduced Terminal Complement Complex Formation in Mice Manifests in Low Bone Mass and Impaired Fracture Healing. Am J Pathol. 2019 Jan;189(1):147-161

TSS for Cd59a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19204	Chr2:103926141-103926150 (+)	0 bp
Tssr19205	Chr2:103926157-103926224 (+)	45 bp
Tssr19206	Chr2:103927273-103927301 (+)	1,141 bp
Tssr19207	Chr2:103942565-103942584 (+)	16,429 bp
Tssr19208	Chr2:103943699-103943712 (+)	17,560 bp

Cd59a is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Actre2	Chr2, 57.65 cM	Chr2:80005954-80006113	J:98587	Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to 6 previously identified alcohol-related QTLs to identify potential candidate genes. Two different Affymetrix microarrays were used in the analysis. Brain expression data from parental strains and 56 (DBA/2J x C57BL/6J)F2 intercross animals were used for analysis. On mouse Chromosome 2, the highest priority candidate genes identified for Actre2 at 48 cM are Cd59a (55 cM) and Scg5 (64 cM). Other candidate genes with a ranking of modest priority were identified but are not listed here.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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