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Fgf14 Gene Detail
Summary
  • Symbol
    Fgf14
  • Name
    fibroblast growth factor 14
  • Synonyms
    Fhf4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109189
    NCBI Gene: 14169
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:124215319-124914539 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 66.18 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12170 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109189
 protein coding gene Chr14:124211257-124915098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021679
 protein coding gene Chr14:121893853-122609944 (-)
A/J MGP_AJ_G0021639
 protein coding gene Chr14:117190959-117922999 (-)
AKR/J MGP_AKRJ_G0021615
 protein coding gene Chr14:120995368-121723955 (-)
BALB/cJ MGP_BALBcJ_G0021645
 protein coding gene Chr14:117764984-118486326 (-)
C3H/HeJ MGP_C3HHeJ_G0021422
 protein coding gene Chr14:120877654-121624901 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022085
 protein coding gene Chr14:126569478-127309384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019623
 protein coding gene Chr14:112903556-113536656 (-)
CAST/EiJ MGP_CASTEiJ_G0020938
 protein coding gene Chr14:118737964-119445164 (-)
CBA/J MGP_CBAJ_G0021391
 protein coding gene Chr14:131398777-132149715 (-)
DBA/2J MGP_DBA2J_G0021514
 protein coding gene Chr14:117045601-117746394 (-)
FVB/NJ MGP_FVBNJ_G0021492
 protein coding gene Chr14:115392704-116081023 (-)
LP/J MGP_LPJ_G0021582
 protein coding gene Chr14:122818894-123557041 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021519
 protein coding gene Chr14:136446546-137399285 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022108
 protein coding gene Chr14:120511308-121223519 (-)
PWK/PhJ MGP_PWKPhJ_G0020682
 protein coding gene Chr14:114052666-114735228 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020520
 protein coding gene Chr14:116686028-117442532 (-)
WSB/EiJ MGP_WSBEiJ_G0020994
 protein coding gene Chr14:121173654-121912710 (-)



Homology
more
  • Human Ortholog
    FGF14, fibroblast growth factor 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF14, fibroblast growth factor 14
  • Synonyms
    FGF-14, FHF-4, FHF4, NYS4, SCA27, SCA27A, SCA27B
  • Links
    NCBI Gene ID: 2259
    neXtProt AC: NX_Q92915
    UniProt: Q92915

  • Chr Location
    13q33.1; chr13:101710804-102402457 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fgf14 mouse models; 1 with human FGF14 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 2 alleles in 4 genetic backgrounds
    37 phenotypes from multigenic genotypes
    178 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display impaired balance and grip strength.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1106
  • Tissues
    165
  • cDNA Data
    18
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025551 Ensembl Gene Model | MGI Sequence Detail 699221 C57BL/6J ±  kb
    transcript ENSMUST00000095529 Ensembl | MGI Sequence Detail 3608 Not Applicable  
    polypeptide ENSMUSP00000093185 Ensembl | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 20
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38233, MGI:4819832
    References
    more
    • Summaries
      All 229
      Developmental Gene Expression 24
      Diseases 4
      Gene Ontology 9
      Phenotypes 178
    • Earliest
      J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9850-7
    • Latest
      J:353285 Zwang TJ, et al., Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology. Cell Rep. 2024 Aug 2;43(8):114574
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory