Ywhah Gene Detail

Summary

• Symbol
  Ywhah
• Name
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
• Synonyms
  14-3-3 eta

• Feature Type
  protein coding gene
• IDs
  MGI:109194
  NCBI Gene: 22629
• Alliance
  gene page
• Transcription Start Sites
  5 TSS

Location &
Maps

• Sequence Map
  Chr5:33176160-33185310 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 17.42 cM, cytoband B1
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  217 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109194	protein coding gene	Chr5:33176160-33185310 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029440	protein coding gene	Chr5:31169943-31179006 (+)
A/J	MGP_AJ_G0029407	protein coding gene	Chr5:30162082-30164262 (+)
AKR/J	MGP_AKRJ_G0029356	protein coding gene	Chr5:31322736-31335172 (+)
BALB/cJ	MGP_BALBcJ_G0029417	protein coding gene	Chr5:30690888-30693068 (+)
C3H/HeJ	MGP_C3HHeJ_G0029139	protein coding gene	Chr5:31367136-31369316 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029871	protein coding gene	Chr5:33034358-33045219 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027108	protein coding gene	Chr5:27968857-27977815 (+)
CAST/EiJ	MGP_CASTEiJ_G0028548	protein coding gene	Chr5:30443496-30445680 (+)
CBA/J	MGP_CBAJ_G0029107	protein coding gene	Chr5:33724601-33726781 (+)
DBA/2J	MGP_DBA2J_G0029255	protein coding gene	Chr5:30349016-30358179 (+)
FVB/NJ	MGP_FVBNJ_G0029214	protein coding gene	Chr5:29757673-29767559 (+)
LP/J	MGP_LPJ_G0029340	protein coding gene	Chr5:31588679-31590859 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029244	protein coding gene	Chr5:34584296-34596218 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028129	protein coding gene	Chr3:98574867-98581992 (+)
PWK/PhJ	MGP_PWKPhJ_G0028273	protein coding gene	Chr5:29467795-29477202 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028104	protein coding gene	Chr5:30285709-30295937 (+)
WSB/EiJ	MGP_WSBEiJ_G0028629	protein coding gene	Chr5:30900573-30902753 (+)

Homology

• Human Ortholog
  YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  YWHAH, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  
• Synonyms
  YWHA1
• Links
  HGNC:12853

  NCBI Gene ID: 7533

  neXtProt AC: NX_Q04917

  UniProt: Q04917

  
  
• Chr Location
  22q12.3; chr22:31944522-31957603 (+)  GRCh38

---

• MGI Vertebrate Homology
  Ywhah stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: YWHAH
• Protein SuperFamily
  14-3-3
• Gene Tree
  Ywhah
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 2 genetic backgrounds
  31 phenotype references
  

• All Mutations and Alleles
  21
• Chemically induced (ENU)
  1
• Chemically induced (other)
  2
• Endonuclease-mediated
  2
• Gene trapped
  11
• Radiation induced
  2
• Spontaneous
  1
• Targeted
  2
• Genomic Mutations
  6 involving Ywhah
• Find Mice (IMSR)
  30 strains or lines available

Mice homozygous for a null allele exhibit normal oogenesis, in vitro oocyte maturation and in vivo breeding.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  51
• GO References
  14

Expression

• Assay Results
  932
• Tissues
  180
• cDNA Data
  254
• Literature Summary
  8

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GENSAT
  GEO
  Expression Atlas
• Other Vertebrate Links
  GEISHA YWHAH
  Xenbase ywhah
  ZFIN ywhah

Sequences &
Gene Models

• All Sequences
  49
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS19198.1

• Ensembl
  ENSMUSG00000018965 (Evidence)
• NCBI Gene
  22629

Representative Sequences			Length	Strain/Species
genomic	22629	NCBI Gene Model | MGI Sequence Detail	9151	C57BL/6J
transcript	NM_011738	RefSeq | MGI Sequence Detail	1806	C57BL/6
polypeptide	P68510	UniProt | EBI | MGI Sequence Detail	246	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000017551 14-3-3 protein eta
  (term hierarchy)
• PDB
  5YQG
• InterPro Domains
  IPR023410 14-3-3 domain
  IPR036815 14-3-3 domain superfamily
  IPR000308 14-3-3 protein
  IPR023409 14-3-3 protein, conserved site
• GlyGen
  P68510 1 site, 1 O-linked glycan (1 site)

Molecular
Reagents

• All nucleic 257

  cDNA 254

  Primer pair 2

  Other 1

  
  

  Microarray probesets 4

Other
Accession IDs

MGD-MRK-38238

References

• Summaries
  All 86

  Developmental Gene Expression 8

  Diseases 1

  Gene Ontology 14

  Phenotypes 31
• Earliest
  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
• Latest
  J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887

TSS for Ywhah:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45801	Chr5:33176113-33176114 (+)	-46 bp
Tssr45802	Chr5:33176178-33176209 (+)	34 bp
Tssr45803	Chr5:33176211-33176229 (+)	60 bp
Tssr45804	Chr5:33176231-33176247 (+)	79 bp
Tssr45805	Chr5:33176290-33176309 (+)	140 bp