Tradd MGI Mouse Gene Detail - MGI:109200 - TNFRSF1A-associated via death domain

Symbol

Tradd
Name

TNFRSF1A-associated via death domain
Synonyms

9130005N23Rik

Feature Type

protein coding gene
IDs

MGI:109200
NCBI Gene: 71609
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr8:105985207-105991226 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 53.04 cM
Mapping Data

3 experiments

SNPs within 2kb

211 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109200	protein coding gene	Chr8:105984918-105991241 (-)
129S1/SvImJ	ENSMUSG00200014682	protein coding gene	Chr8:100264452-100270788 (-)
A/J	ENSMUSG00195003455	protein coding gene	Chr8:100586950-100593290 (-)
AKR/J	ENSMUSG00220011590	protein coding gene	Chr8:100720809-100727143 (-)
BALB/cJ	ENSMUSG00180022145	protein coding gene	Chr8:100592700-100599031 (-)
C3H/HeJ	ENSMUSG00175022298	protein coding gene	Chr8:100649490-100655821 (-)
C57BL/6NJ	ENSMUSG00215001179	protein coding gene	Chr8:100263817-100270145 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031467	protein coding gene	Chr8:96385033-96391225 (-)
CAST/EiJ	ENSTCUG00005021559	protein coding gene	Chr8:100030630-100037008 (-)
CBA/J	ENSMUSG00210032195	protein coding gene	Chr8:100577179-100583511 (-)
DBA/2J	ENSMUSG00185005205	protein coding gene	Chr8:106685982-106692309 (-)
FVB/NJ	ENSMUSG00205015602	protein coding gene	Chr8:99561448-99567780 (-)
JF1/MsJ	ENSUMUG00000005923	protein coding gene	Chr8:109019175-109025500 (-)
LP/J	ENSMUSG00230007077	protein coding gene	Chr8:110366386-110372717 (-)
NOD/ShiLtJ	ENSMUSG00190021102	protein coding gene	Chr8:100716391-100722721 (-)
NZO/HlLtJ	ENSMUSG00225018125	protein coding gene	Chr8:113716962-113723277 (-)
PWK/PhJ	ENSLUMG00010003461	protein coding gene	Chr8:100498684-100504971 (-)
SPRET/EiJ	ENSMSPG00010030104	protein coding gene	Chr8:102580631-102586316 (-)
WSB/EiJ	ENSIUOG00005030968	protein coding gene	Chr8:101389070-101395411 (-)

Human Ortholog

TRADD, TNFRSF1A associated via death domain

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRADD, TNFRSF1A associated via death domain
Synonyms

Hs.89862
Links

HGNC:12030

NCBI Gene ID: 8717

UniProt: Q15628
Chr Location

16q22.1; chr16:67153969-67163760 (-) GRCh38

MGI Vertebrate Homology

Tradd stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRADD
Gene Tree

Tradd

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Phenotype Summary

14 phenotypes from 3 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
20 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

2
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mutations can cause resistance to toxicity induced by TNF, LPS and poly(I:C), resistance to galactosamine and TNF-induced hepatitis, increased susceptibility to bacterial infection, and impaired formation of follicular dendritic cell networksand germinal centers in spleen.

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All GO Annotations

77
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

634
Tissues

22
cDNA Data

36
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tradd

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All Sequences

44
RefSeq

2
UniProt

4
CCDS

CCDS22594.1

Ensembl

ENSMUSG00000031887 (Evidence)
NCBI Gene

71609

			Length	Strain/Species	Flank
genomic	71609	NCBI Gene Model \| MGI Sequence Detail	6020	C57BL/6J	± kb
transcript	NM_001033161	RefSeq \| MGI Sequence Detail	1385	ZRU/MplStud
polypeptide	Q3U0V2	UniProt \| EBI \| MGI Sequence Detail	310	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000002233 tumor necrosis factor receptor type 1-associated DEATH domain protein

(term hierarchy)
InterPro Domains

IPR000488 Death domain

IPR011029 Death-like domain superfamily

IPR035712 TRADD

IPR009095 TRADD, N-terminal

IPR036729 TRADD, N-terminal domain superfamily
GlyGen

Q3U0V2 1 site, 1 O-linked glycan (1 site)

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All nucleic 39

Genomic 1

cDNA 36

Primer pair 2

Antibodies 2

Microarray probesets 4

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MGD-MRK-38244, MGI:1918859, MGI:2142447

Summaries

All 93

Developmental Gene Expression 7

Gene Ontology 21

Phenotypes 20
Earliest

J:21378 Tebo JM, et al., Murine inhibitory protein-kappa B alpha negatively regulates kappa B-dependent transcription in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Immunol. 1994 Nov 15;153(10):4713-20
Latest

J:373046 Acuna-Pilarte K, et al., HAF prevents hepatocyte apoptosis and progression to MASH and HCC through transcriptional regulation of the NF-kappaB pathway. Hepatology. 2025 Aug 1;82(2):438-453

TSS for Tradd:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr82629	Chr8:105991218-105991250 (-)	-8 bp
Tssr82628	Chr8:105991210-105991217 (-)	12 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24