About   Help   FAQ
Npas1 Gene Detail
Summary
  • Symbol
    Npas1
  • Name
    neuronal PAS domain protein 1
  • Synonyms
    bHLHe11, MOP5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109205
    NCBI Gene: 18142
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16189643-16210741 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.14 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    622 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109205
 protein coding gene Chr7:16189643-16211653 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031711
 protein coding gene Chr7:14168115-14190011 (-)
A/J MGP_AJ_G0031683
 protein coding gene Chr7:13928911-13949649 (-)
AKR/J MGP_AKRJ_G0031608
 protein coding gene Chr7:14249721-14270792 (-)
BALB/cJ MGP_BALBcJ_G0031690
 protein coding gene Chr7:14035908-14056674 (-)
C3H/HeJ MGP_C3HHeJ_G0031412
 protein coding gene Chr7:14436807-14460569 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032156
 protein coding gene Chr7:14915271-14936065 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029235
 protein coding gene Chr7:15477309-15499045 (-)
CAST/EiJ MGP_CASTEiJ_G0030763
 protein coding gene Chr7:11198107-11221292 (-)
CBA/J MGP_CBAJ_G0031371
 protein coding gene Chr7:15381784-15408967 (-)
DBA/2J MGP_DBA2J_G0031527
 protein coding gene Chr7:13813976-13836361 (-)
FVB/NJ MGP_FVBNJ_G0031483
 protein coding gene Chr7:13714127-13737177 (-)
LP/J MGP_LPJ_G0031612
 protein coding gene Chr7:14414213-14438355 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031518
 protein coding gene Chr7:15330833-15354674 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032185
 protein coding gene Chr7:14027484-14048599 (-)
PWK/PhJ MGP_PWKPhJ_G0030487
 protein coding gene Chr7:11338506-11360497 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030314
 protein coding gene Chr7:8941679-8964872 (-)
WSB/EiJ MGP_WSBEiJ_G0030860
 protein coding gene Chr7:14085928-14109322 (-)



Homology
more
  • Human Ortholog
    NPAS1, neuronal PAS domain protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPAS1, neuronal PAS domain protein 1
  • Synonyms
    bHLHe11, MOP5, PASD5
  • Links
    NCBI Gene ID: 4861
    neXtProt AC: NX_Q99742
    UniProt: Q99742

  • Chr Location
    19q13.32; chr19:47019837-47045775 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from multigenic genotypes
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    161
  • cDNA Data
    12
  • Literature Summary
    24
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18142 NCBI Gene Model | MGI Sequence Detail 21099 C57BL/6J ±  kb
transcript NM_008718 RefSeq | MGI Sequence Detail 2091 ZRU/MplStud  
polypeptide P97459 UniProt | EBI | MGI Sequence Detail 594 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 4
    cDNA 12
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38249
References
more
  • Summaries
    All 57
    Developmental Gene Expression 24
    Gene Ontology 6
    Phenotypes 8
  • Earliest
    J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
  • Latest
    J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory