Npas2 MGI Mouse Gene Detail - MGI:109232 - neuronal PAS domain protein 2

Symbol

Npas2
Name

neuronal PAS domain protein 2
Synonyms

bHLHe9, MOP4

Feature Type

protein coding gene
IDs

MGI:109232
NCBI Gene: 18143
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:39233013-39402321 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 17.98 cM
Mapping Data

3 experiments

SNPs within 2kb

5291 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109232	protein coding gene	Chr1:39232812-39402321 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015955	protein coding gene	Chr1:37916096-38097715 (+)
A/J	MGP_AJ_G0015939	protein coding gene	Chr1:36856821-37029952 (+)
AKR/J	MGP_AKRJ_G0015894	protein coding gene	Chr1:37367251-37539201 (+)
BALB/cJ	MGP_BALBcJ_G0015893	protein coding gene	Chr1:36511042-36681299 (+)
C3H/HeJ	MGP_C3HHeJ_G0015726	protein coding gene	Chr1:37600964-37780246 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016346	protein coding gene	Chr1:39507798-39686440 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014068	protein coding gene	Chr1:33827910-33992601 (+)
CAST/EiJ	MGP_CASTEiJ_G0015307	protein coding gene	Chr1:37486555-37669462 (+)
CBA/J	MGP_CBAJ_G0015698	protein coding gene	Chr1:40642431-40828302 (+)
DBA/2J	MGP_DBA2J_G0015799	protein coding gene	Chr1:36147833-36319598 (+)
FVB/NJ	MGP_FVBNJ_G0015801	protein coding gene	Chr1:35681959-35855557 (+)
LP/J	MGP_LPJ_G0015869	protein coding gene	Chr1:38261178-38439109 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015821	protein coding gene	Chr1:42715099-42893592 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016393	protein coding gene	Chr1:37470936-37651377 (+)
PWK/PhJ	MGP_PWKPhJ_G0015090	protein coding gene	Chr1:35954462-36129740 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014872	protein coding gene	Chr1:37396135-37579342 (+)
WSB/EiJ	MGP_WSBEiJ_G0015369	protein coding gene	Chr1:37415084-37593480 (+)

Human Ortholog

NPAS2, neuronal PAS domain protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NPAS2, neuronal PAS domain protein 2
Synonyms

bHLHe9, MOP4, PASD4
Links

HGNC:7895

NCBI Gene ID: 4862

neXtProt AC: NX_Q99743

UniProt: Q99743
Chr Location

2q11.2; chr2:100818723-100996829 (+) GRCh38

MGI Vertebrate Homology

Npas2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NPAS2
Gene Tree

Npas2

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Phenotype Summary

24 phenotypes from 2 alleles in 4 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Npas2
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted mutation of this gene results in deficits in complex emotional long-term memory tasks

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All GO Annotations

38
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

985
Tissues

246
cDNA Data

15
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA NPAS2

Xenbase npas2

ZFIN npas2

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All Sequences

40
RefSeq

4
UniProt

5
CCDS

CCDS48244.1

Ensembl

ENSMUSG00000026077 (Evidence)
NCBI Gene

18143

			Length	Strain/Species	Flank
genomic	18143	NCBI Gene Model \| MGI Sequence Detail	169309	C57BL/6J	± kb
transcript	NM_008719	RefSeq \| MGI Sequence Detail	4180	ZRU/MplStud
polypeptide	P97460	UniProt \| EBI \| MGI Sequence Detail	816	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011350 neuronal PAS domain-containing protein 2

(term hierarchy)
InterPro Domains

IPR047230 Circadian locomoter output cycles protein kaput-like

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR001067 Nuclear translocator

IPR001610 PAC motif

IPR000014 PAS domain

IPR035965 PAS domain superfamily

IPR013767 PAS fold

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All nucleic 19

cDNA 16

Primer pair 3

Microarray probesets 4

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MGD-MRK-38276

Summaries

All 76

Developmental Gene Expression 12

Gene Ontology 13

Phenotypes 33
Earliest

J:37770 Zhou YD, et al., Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):713-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Npas2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6371	Chr1:39232820-39232879 (+)	-163 bp
Tssr56	Chr1:39277623-39277625 (+)	44,611 bp
Tssr6372	Chr1:39311988-39311992 (+)	78,977 bp
Tssr6373	Chr1:39391525-39391526 (+)	158,513 bp
Tssr6374	Chr1:39402073-39402078 (+)	169,063 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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