Spin1 MGI Mouse Gene Detail - MGI:109242

Symbol

Spin1
Name

spindlin 1
Synonyms

Spin

Feature Type

protein coding gene
IDs

MGI:109242
NCBI Gene: 20729
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:51254916-51306582 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 26.04 cM
Mapping Data

3 experiments

SNPs within 2kb

1007 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109242	protein coding gene	Chr13:51254523-51306588 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020547	protein coding gene	Chr13:50279173-50329545 (+)
A/J	MGP_AJ_G0020501	protein coding gene	Chr13:48514483-48566572 (+)
AKR/J	MGP_AKRJ_G0020479	protein coding gene	Chr13:49892895-49950040 (+)
BALB/cJ	MGP_BALBcJ_G0020497	protein coding gene	Chr13:48683930-48758107 (+)
C3H/HeJ	MGP_C3HHeJ_G0020297	protein coding gene	Chr13:49721286-49773933 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020931	protein coding gene	Chr13:51843082-51896615 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018513	protein coding gene	Chr13:46311134-46359992 (+)
CAST/EiJ	MGP_CASTEiJ_G0019810	protein coding gene	Chr13:49675281-49728973 (+)
CBA/J	MGP_CBAJ_G0020256	protein coding gene	Chr13:53862296-53915223 (+)
DBA/2J	MGP_DBA2J_G0020379	protein coding gene	Chr13:48067997-48124754 (+)
FVB/NJ	MGP_FVBNJ_G0020358	protein coding gene	Chr13:47501488-47557062 (+)
LP/J	MGP_LPJ_G0020455	protein coding gene	Chr13:50553142-50607499 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020387	protein coding gene	Chr13:53470023-53520150 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020974	protein coding gene	Chr13:49448564-49505115 (+)
PWK/PhJ	MGP_PWKPhJ_G0019567	protein coding gene	Chr13:48000805-48054251 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019394	protein coding gene	Chr13:48352430-48400211 (+)
WSB/EiJ	MGP_WSBEiJ_G0019872	protein coding gene	Chr13:49752672-49808072 (+)

Human Ortholog

SPIN1, spindlin 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SPIN1, spindlin 1
Synonyms

SPIN, TDRD24
Links

HGNC:11243

NCBI Gene ID: 10927

neXtProt AC: NX_Q9Y657

UniProt: Q9Y657
Chr Location

9q22.1; chr9:88388430-88478694 (+) GRCh38

MGI Vertebrate Homology

Spin1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: SPIN1
Gene Tree

Spin1

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Phenotype Summary

34 phenotypes from 4 alleles in 4 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

194
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

185
Targeted

6
Genomic Mutations

1 involving Spin1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

101 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trapped allele display complete postnatal lethality. Although mutant female mice exhibit normal follicular development and oocyte growth, fully grown oocytes are defective in resuming meiosis.

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All GO Annotations

31
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

793
Tissues

55
cDNA Data

339
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase spin1

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All Sequences

94
RefSeq

20
UniProt

6
CCDS

CCDS26510.1

Ensembl

ENSMUSG00000021395 (Evidence)
NCBI Gene

20729

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021395	Ensembl Gene Model \| MGI Sequence Detail	51667	C57BL/6J	± kb
transcript	ENSMUST00000095797	Ensembl \| MGI Sequence Detail	4434	Not Applicable
polypeptide	ENSMUSP00000093473	Ensembl \| MGI Sequence Detail	262	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000015527 spindlin-1

(term hierarchy)
InterPro Domains

IPR042567 Spindlin/spermiogenesis-specific domain superfamily

IPR003671 Spindlin/spermiogenesis-specific protein

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All nucleic 343

cDNA 339

Primer pair 4

Microarray probesets 10

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MGD-MRK-38287, MGI:2142957, MGI:2145170

Summaries

All 51

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 17
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:355681 Dias Mirandela M, et al., Two-factor authentication underpins the precision of the piRNA pathway. Nature. 2024 Oct;634(8035):979-985

TSS for Spin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119745	Chr13:51254509-51254528 (+)	-397 bp
Tssr119746	Chr13:51254530-51254551 (+)	-375 bp
Tssr119747	Chr13:51254817-51254835 (+)	-90 bp
Tssr119748	Chr13:51254846-51254969 (+)	-8 bp
Tssr119749	Chr13:51255239-51255267 (+)	337 bp
Tssr119750	Chr13:51286315-51286319 (+)	31,401 bp
Tssr119751	Chr13:51291717-51291721 (+)	36,803 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24