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Sema4c Gene Detail
Summary
  • Symbol
    Sema4c
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
  • Synonyms
    M-Sema F, Semacl1, Semacl1, Semaf, Semai
  • Feature Type
    protein coding gene
  • IDs
    MGI:109252
    NCBI Gene: 20353
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:36587720-36597430 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 15.32 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    247 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109252
 protein coding gene Chr1:36587720-36599780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015928
 protein coding gene Chr1:35087092-35096802 (-)
A/J MGP_AJ_G0015912
 protein coding gene Chr1:34146989-34156692 (-)
AKR/J MGP_AKRJ_G0015867
 protein coding gene Chr1:34629443-34639147 (-)
BALB/cJ MGP_BALBcJ_G0015866
 protein coding gene Chr1:33836648-33846358 (-)
C3H/HeJ MGP_C3HHeJ_G0015699
 protein coding gene Chr1:34824774-34834477 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016319
 protein coding gene Chr1:36674849-36684559 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014041
 protein coding gene Chr1:31199786-31209676 (-)
CAST/EiJ MGP_CASTEiJ_G0015280
 protein coding gene Chr1:34711454-34721178 (-)
CBA/J MGP_CBAJ_G0015671
 protein coding gene Chr1:37630227-37639931 (-)
DBA/2J MGP_DBA2J_G0015772
 protein coding gene Chr1:33482381-33492085 (-)
FVB/NJ MGP_FVBNJ_G0015774
 protein coding gene Chr1:33005905-33015609 (-)
LP/J MGP_LPJ_G0015842
 protein coding gene Chr1:35454779-35464489 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015794
 protein coding gene Chr1:39856176-39865886 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016366
 protein coding gene Chr1:34663523-34673227 (-)
PWK/PhJ MGP_PWKPhJ_G0015063
 protein coding gene Chr1:33235193-33244943 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014845
 protein coding gene Chr1:34613469-34623150 (-)
WSB/EiJ MGP_WSBEiJ_G0015342
 protein coding gene Chr1:34613891-34623596 (-)



Homology
more
  • Human Ortholog
    SEMA4C, semaphorin 4C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA4C, semaphorin 4C
  • Synonyms
    M-SEMA-F, SEMACL1, SEMAF, SEMAI
  • Links
    NCBI Gene ID: 54910
    neXtProt AC: NX_Q9C0C4
    UniProt: Q9C0C4

  • Chr Location
    2q11.2; chr2:96859718-96870830 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation exhibit exencephaly, neonatal lethality, and abnormal cerebellum morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    55
  • cDNA Data
    46
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026121 Ensembl Gene Model | MGI Sequence Detail 9711 C57BL/6J ±  kb
    transcript ENSMUST00000114991 Ensembl | MGI Sequence Detail 3773 Not Applicable  
    polypeptide ENSMUSP00000110643 Ensembl | MGI Sequence Detail 834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 47
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38297, MGI:2138227
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 24
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
    • Latest
      J:341383 Salamon I, et al., Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex. Nat Commun. 2023 Sep 27;14(1):6025
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory