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Trim24 Gene Detail
Summary
  • Symbol
    Trim24
  • Name
    tripartite motif-containing 24
  • Synonyms
    A130082H20Rik, D430004I05Rik, Tif1a, TIF1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:109275
    NCBI Gene: 21848
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:37847746-37943231 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 17.07 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1765 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109275
 protein coding gene Chr6:37846816-37945380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030578
 protein coding gene Chr6:36134943-36236069 (+)
A/J MGP_AJ_G0030551
 protein coding gene Chr6:34577599-34675043 (+)
AKR/J MGP_AKRJ_G0030478
 protein coding gene Chr6:35679019-35776928 (+)
BALB/cJ MGP_BALBcJ_G0030561
 protein coding gene Chr6:34767818-34867393 (+)
C3H/HeJ MGP_C3HHeJ_G0030274
 protein coding gene Chr6:35685250-35787368 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031015
 protein coding gene Chr6:37052407-37155737 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028227
 protein coding gene Chr6:32485781-32591501 (+)
CAST/EiJ MGP_CASTEiJ_G0029676
 protein coding gene Chr6:35537413-35669607 (+)
CBA/J MGP_CBAJ_G0030252
 protein coding gene Chr6:38471282-38580123 (+)
DBA/2J MGP_DBA2J_G0030396
 protein coding gene Chr6:34402457-34497756 (+)
FVB/NJ MGP_FVBNJ_G0030350
 protein coding gene Chr6:34191326-34286540 (+)
LP/J MGP_LPJ_G0030483
 protein coding gene Chr6:36194867-36297776 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030386
 protein coding gene Chr6:40860375-40965917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031045
 protein coding gene Chr6:35598053-35695591 (+)
PWK/PhJ MGP_PWKPhJ_G0029390
 protein coding gene Chr6:34039387-34140542 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029226
 protein coding gene Chr6:35311839-35419583 (+)
WSB/EiJ MGP_WSBEiJ_G0029752
 protein coding gene Chr6:35544412-35645590 (+)



Homology
more
  • Human Ortholog
    TRIM24, tripartite motif containing 24
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM24, tripartite motif containing 24
  • Synonyms
    hTIF1, PTC6, RNF82, TF1A, TIF1, TIF1A, TIF1ALPHA
  • Links
    NCBI Gene ID: 8805
    neXtProt AC: NX_O15164
    UniProt: O15164

  • Chr Location
    7q33-q34; chr7:138460259-138589996 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 4 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased hepatocyte ploidy and uncontrolled hepatocellular proliferation; most adult mice develop malignant hepatocellular carcinomas. Homozygosity for p.C52A + p.C55A or p.S1043A mutations alleviates diet-induced hepatic steatosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    122
  • cDNA Data
    127
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029833 Ensembl Gene Model | MGI Sequence Detail 95486 C57BL/6J ±  kb
    transcript ENSMUST00000031859 Ensembl | MGI Sequence Detail 4042 Not Applicable  
    polypeptide ENSMUSP00000031859 Ensembl | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 137
      cDNA 133
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38320, MGI:1889824, MGI:2442432, MGI:2445188
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 12
      Gene Ontology 19
      Phenotypes 18
    • Earliest
      J:30466 Miki T, et al., Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5167-71
    • Latest
      J:345293 Wei W, et al., TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun. 2022 Jul 8;13(1):3972
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory