Nudt1 MGI Mouse Gene Detail - MGI:109280

Symbol

Nudt1
Name

nudix hydrolase 1
Synonyms

8-oxo-7,8-dihydro-2'-dGTPase, Mth1, nudix (nucleoside diphosphate linked moiety X)-type motif 1

Feature Type

protein coding gene
IDs

MGI:109280
NCBI Gene: 17766
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr5:140307411-140323892 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 78.94 cM, cytoband G1
Mapping Data

2 experiments

SNPs within 2kb

692 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109280	protein coding gene	Chr5:140307375-140323892 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030296	protein coding gene	Chr5:145381606-145398096 (+)
A/J	MGP_AJ_G0030265	protein coding gene	Chr5:139197628-139214096 (+)
AKR/J	MGP_AKRJ_G0030197	protein coding gene	Chr5:143544479-143560949 (+)
BALB/cJ	MGP_BALBcJ_G0030282	protein coding gene	Chr5:140442533-140459013 (+)
C3H/HeJ	MGP_C3HHeJ_G0029993	protein coding gene	Chr5:144321100-144338163 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030727	protein coding gene	Chr5:150768817-150785284 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027945	protein coding gene	Chr5:133043699-133061096 (+)
CAST/EiJ	MGP_CASTEiJ_G0029398	protein coding gene	Chr5:143754896-143771247 (+)
CBA/J	MGP_CBAJ_G0029963	protein coding gene	Chr5:156956822-156973293 (+)
DBA/2J	MGP_DBA2J_G0030113	protein coding gene	Chr5:139009947-139026646 (+)
FVB/NJ	MGP_FVBNJ_G0030068	protein coding gene	Chr5:138152593-138169357 (+)
LP/J	MGP_LPJ_G0030199	protein coding gene	Chr5:145995394-146012616 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030099	protein coding gene	Chr5:159550887-159568876 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030767	protein coding gene	Chr5:143376510-143392994 (+)
PWK/PhJ	MGP_PWKPhJ_G0029113	protein coding gene	Chr5:138030995-138048341 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028949	protein coding gene	Chr5:141072056-141092397 (+)
WSB/EiJ	MGP_WSBEiJ_G0029472	protein coding gene	Chr5:144160206-144177578 (+)

Human Ortholog

NUDT1, nudix hydrolase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUDT1, nudix hydrolase 1
Synonyms

MTH1
Links

HGNC:8048

NCBI Gene ID: 4521

neXtProt AC: NX_P36639

UniProt: P36639
Chr Location

7p22.3; chr7:2242226-2251146 (+) GRCh38

MGI Vertebrate Homology

Nudt1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUDT1
Gene Tree

Nudt1

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Phenotype Summary

6 phenotypes from 1 allele in 3 genetic backgrounds
10 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Gene trapped

45
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Aging mice homozygous for a knock-out allele show increased incidence of tumor formation in the lung, liver and stomach.

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All GO Annotations

42
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

14
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nudt1

ZFIN nudt1

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All Sequences

57
RefSeq

10
UniProt

3
CCDS

CCDS19818.1

Ensembl

ENSMUSG00000036639 (Evidence)
NCBI Gene

17766

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036639	Ensembl Gene Model \| MGI Sequence Detail	16482	C57BL/6J	± kb
transcript	ENSMUST00000071881	Ensembl \| MGI Sequence Detail	952	Not Applicable
polypeptide	ENSMUSP00000071778	Ensembl \| MGI Sequence Detail	156	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011483 oxidized purine nucleoside triphosphate hydrolase

(term hierarchy)
PDB

5MZE, 5MZG, 6EHH
EC

3.6.1.-, 3.6.1.56
InterPro Domains

IPR020476 NUDIX hydrolase

IPR020084 NUDIX hydrolase, conserved site

IPR000086 NUDIX hydrolase domain

IPR015797 NUDIX hydrolase-like domain superfamily

IPR003563 Oxidized purine nucleoside triphosphate

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGD-MRK-38325

Summaries

All 61

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 22
Earliest

J:29544 Kakuma T, et al., Mouse MTH1 protein with 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphatase activity that prevents transversion mutation. cDNA cloning and tissue distribution. J Biol Chem. 1995 Oct 27;270(43):25942-8
Latest

J:355460 Ding Y, et al., MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis. Nat Commun. 2023 Aug 10;14(1):4829

TSS for Nudt1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49539	Chr5:140307369-140307426 (+)	-13 bp
Tssr49540	Chr5:140317653-140317694 (+)	10,263 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24