Cd244a MGI Mouse Gene Detail - MGI:109294

Symbol

Cd244a
Name

CD244 molecule A
Synonyms

2B4, C9.1, Cd244, F730046O15Rik, Nmrk

Feature Type

protein coding gene
IDs

MGI:109294
NCBI Gene: 18106
Alliance

genome feature page
Transcription Start Sites

9 TSS
Candidate for QTL

1 QTL

Sequence Map

Chr1:171386761-171412884 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.52 cM
Mapping Data

8 experiments

SNPs within 2kb

1307 from dbSNP Build 142
Strain Annotations

29

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109294	protein coding gene	Chr1:171386761-171437314 (+)
129S1/SvImJ	ENSMUSG00200045154	protein coding gene	Chr1:169312785-169364730 (+)
129S1/SvImJ	ENSMUSG00200045120	protein coding gene	Chr1:169338308-169339871 (+)
A/J	ENSMUSG00195047584	protein coding gene	Chr1:168633253-168685250 (+)
A/J	ENSMUSG00195047546	protein coding gene	Chr1:168658803-168660365 (+)
AKR/J	ENSMUSG00220029111	protein coding gene	Chr1:168356929-168408899 (+)
AKR/J	ENSMUSG00220028998	protein coding gene	Chr1:168382463-168384026 (+)
BALB/cJ	ENSMUSG00180041665	protein coding gene	Chr1:168978617-168980181 (+)
BALB/cJ	ENSMUSG00180041722	protein coding gene	Chr1:168953088-169005041 (+)
C3H/HeJ	ENSMUSG00175038674	protein coding gene	Chr1:168964108-169016066 (+)
C3H/HeJ	ENSMUSG00175038652	protein coding gene	Chr1:168989635-168991198 (+)
C57BL/6NJ	ENSMUSG00215043727	protein coding gene	Chr1:168343881-168394437 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014875	protein coding gene	Chr1:161765803-161875825 (+)
CAST/EiJ	ENSTCUG00005045064	protein coding gene	Chr1:166907783-166959456 (+)
CBA/J	ENSMUSG00210037069	protein coding gene	Chr1:168856829-168858393 (+)
CBA/J	ENSMUSG00210037123	protein coding gene	Chr1:168831323-168883267 (+)
DBA/2J	ENSMUSG00185027922	protein coding gene	Chr1:173133420-173185367 (+)
DBA/2J	ENSMUSG00185027906	protein coding gene	Chr1:173158930-173160494 (+)
FVB/NJ	ENSMUSG00205033947	protein coding gene	Chr1:167792126-167844099 (+)
JF1/MsJ	ENSUMUG00000008379	protein coding gene	Chr1:172059562-172110115 (+)
LP/J	ENSMUSG00230024237	protein coding gene	Chr1:172729856-172781810 (+)
LP/J	ENSMUSG00230024146	protein coding gene	Chr1:172755379-172756942 (+)
NOD/ShiLtJ	ENSMUSG00190034964	protein coding gene	Chr1:168639725-168691684 (+)
NOD/ShiLtJ	ENSMUSG00190034896	protein coding gene	Chr1:168665244-168666809 (+)
NZO/HlLtJ	ENSMUSG00225004451	protein coding gene	Chr1:176342278-176343840 (+)
NZO/HlLtJ	ENSMUSG00225004461	protein coding gene	Chr1:176316736-176368713 (+)
PWK/PhJ	ENSLUMG00010031702	protein coding gene	Chr1:167599925-167651893 (+)
SPRET/EiJ	ENSMSPG00010044335	protein coding gene	Chr1:170956384-171009300 (+)
WSB/EiJ	ENSIUOG00005038184	protein coding gene	Chr1:167979391-168031290 (+)

Human Ortholog

CD244, CD244 molecule

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD244, CD244 molecule
Synonyms

2B4, NAIL, NKR2B4, Nmrk, SLAMF4
Links

HGNC:18171

NCBI Gene ID: 51744

UniProt: Q9BZW8
Chr Location

1q23.3; chr1:160830160-160862904 (-) GRCh38

MGI Vertebrate Homology

Cd244a stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD244
Gene Tree

Cd244a

Diseases

1 with human CD244 associations

				Human Disease	Mouse Models
				rheumatoid arthritis IDs rheumatoid arthritis DOID:7148 EFO:0000685 ICD10CM:M06.9 ICD9CM:714.0 KEGG:05323 MESH:D001172 NCI:C2884 OMIM:180300 UMLS_CUI:C0003873

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

4
Targeted

5
Genomic Mutations

3 involving Cd244a
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Mice homozygous for a knock-out allele exhibit altered natural killer (NK) cell cytolysis. Mice homozygous for an ENU-generated allele exhibit reduced 'missing-self' targets recognition and elimination and increased clearance of B16 melanoma tumors.

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All GO Annotations

30
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

601
Tissues

1
cDNA Data

13
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

76
RefSeq

6
UniProt

10
CCDS

CCDS35778.1

Ensembl

ENSMUSG00000004709 (Evidence)
NCBI Gene

18106

			Length	Strain/Species	Flank
genomic	18106	NCBI Gene Model \| MGI Sequence Detail	26124	C57BL/6J	± kb
transcript	NR_187115	RefSeq \| MGI Sequence Detail	3833	C57BL/6
polypeptide	Q07763	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000001896 natural killer cell receptor 2B4

(term hierarchy)
PDB

1Z2K, 2PTT, 2PTU
InterPro Domains

IPR015631 CD2/SLAM family receptor

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR024303 Natural killer cell receptor 2B4, immunoglobulin domain
GlyGen

Q07763 7 sites

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All nucleic 14

Genomic 1

cDNA 13

Microarray probesets 4

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MGD-MRK-38339, MGI:2442562, MGI:6159378

Summaries

All 105

Developmental Gene Expression 1

Gene Ontology 11

Phenotypes 36
Earliest

J:15522 Mathew PA, et al., Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol. 1993 Nov 15;151(10):5328-37
Latest

J:377135 Zhu K, et al., CD2 and its ligands are involved in development and activation of MAIT cells. J Exp Med. 2025 Dec 1;222(12):e20250431

TSS for Cd244a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10062	Chr1:171386480-171386498 (+)	-272 bp
Tssr10063	Chr1:171386664-171386688 (+)	-85 bp
Tssr10064	Chr1:171386700-171386718 (+)	-52 bp
Tssr10065	Chr1:171386728-171386749 (+)	-22 bp
Tssr10066	Chr1:171386754-171386773 (+)	3 bp
Tssr10067	Chr1:171386785-171386802 (+)	33 bp
Tssr10068	Chr1:171386811-171386842 (+)	66 bp
Tssr10069	Chr1:171386866-171386873 (+)	109 bp
Tssr10070	Chr1:171408099-171408101 (+)	21,339 bp

Cd244a is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Sle1b	Chr1, 75.10 cM		J:94686	Congenic and physical mapping was used to show that Sle1b mapped within an interval containing SLAM family members ordered as Cd244 - Ly9 - Slamf7 - Cd48 - Slamf1 - Cd84 - Slamf6. Haplotype analysis of the aformentioned region were suggestive that the markers contained within the region as contributing to the Sle1b phenotype. The strongest contribution may come from Slamf6.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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