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Sall3 Gene Detail
Summary
  • Symbol
    Sall3
  • Name
    spalt like transcription factor 3
  • Synonyms
    B130022O04Rik, Msal, Msal-1, Salt, Spalt
  • Feature Type
    protein coding gene
  • IDs
    MGI:109295
    NCBI Gene: 20689
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:81010204-81030236 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 54.11 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109295
 protein coding gene Chr18:81009591-81030236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024599
 protein coding gene Chr18:81902984-81924417 (-)
A/J MGP_AJ_G0024566
 protein coding gene Chr18:78322303-78342510 (-)
AKR/J MGP_AKRJ_G0024537
 protein coding gene Chr18:80660579-80680779 (-)
BALB/cJ MGP_BALBcJ_G0024564
 protein coding gene Chr18:78504907-78525391 (-)
C3H/HeJ MGP_C3HHeJ_G0024333
 protein coding gene Chr18:80745744-80765972 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025011
 protein coding gene Chr18:83985440-84007783 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022442
 protein coding gene Chr18:77158362-77178490 (-)
CAST/EiJ MGP_CASTEiJ_G0023806
 protein coding gene Chr18:81084294-81105178 (-)
CBA/J MGP_CBAJ_G0024303
 protein coding gene Chr18:87050701-87075529 (-)
DBA/2J MGP_DBA2J_G0024433
 protein coding gene Chr18:77872304-77892771 (-)
FVB/NJ MGP_FVBNJ_G0024399
 protein coding gene Chr18:77184573-77204633 (-)
LP/J MGP_LPJ_G0024517
 protein coding gene Chr18:81765109-81786893 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024429
 protein coding gene Chr18:88309724-88330288 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025060
 protein coding gene Chr18:80813748-80837509 (-)
PWK/PhJ MGP_PWKPhJ_G0023551
 protein coding gene Chr18:78273528-78294043 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023357
 protein coding gene Chr18:80991038-81012642 (-)
WSB/EiJ MGP_WSBEiJ_G0023868
 protein coding gene Chr18:80769144-80791597 (-)



Homology
more
  • Human Ortholog
    SALL3, spalt like transcription factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SALL3, spalt like transcription factor 3
  • Synonyms
    ZNF796
  • Links
    NCBI Gene ID: 27164
    neXtProt AC: NX_Q9BXA9
    UniProt: Q9BXA9

  • Chr Location
    18q23; chr18:78979818-79002677 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display neonatal lethality with an impaired suckling ability, truncated soft palate, small epiglottis, and abnormal cranial nerve morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1151
  • Tissues
    216
  • cDNA Data
    42
  • Literature Summary
    42
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20689 NCBI Gene Model | MGI Sequence Detail 20033 C57BL/6J ±  kb
    transcript NM_001369133 RefSeq | MGI Sequence Detail 6924 C57BL/6  
    polypeptide Q62255 UniProt | EBI | MGI Sequence Detail 1320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 1
      cDNA 45
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36133, MGD-MRK-38340, MGI:2442452
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 42
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:33754 Ott T, et al., The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures. Mech Dev. 1996 May;56(1-2):117-28
    • Latest
      J:354180 Xu M, et al., ISL1 and POU4F1 Directly Interact to Regulate the Differentiation and Survival of Inner Ear Sensory Neurons. J Neurosci. 2024 Feb 21;44(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory