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Polr2c Gene Detail
Summary
  • Symbol
    Polr2c
  • Name
    polymerase (RNA) II (DNA directed) polypeptide C
  • Synonyms
    33kDa, mRBP31, RPB3, Rpo2-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109299
    NCBI Gene: 20021
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:95584078-95590870 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109299
 protein coding gene Chr8:95584078-95600163 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033972
 protein coding gene Chr8:96298523-96305406 (+)
A/J MGP_AJ_G0033955
 protein coding gene Chr8:92545924-92552697 (+)
AKR/J MGP_AKRJ_G0033881
 protein coding gene Chr8:95065002-95075887 (+)
BALB/cJ MGP_BALBcJ_G0033947
 protein coding gene Chr8:92627429-92634169 (+)
C3H/HeJ MGP_C3HHeJ_G0033657
 protein coding gene Chr8:95781559-95788276 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034468
 protein coding gene Chr8:99808401-99816723 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031409
 protein coding gene Chr8:86348174-86355188 (+)
CAST/EiJ MGP_CASTEiJ_G0032989
 protein coding gene Chr8:95385375-95392178 (+)
CBA/J MGP_CBAJ_G0033633
 protein coding gene Chr8:103099675-103110985 (+)
DBA/2J MGP_DBA2J_G0033787
 protein coding gene Chr8:92004830-92032084 (+)
FVB/NJ MGP_FVBNJ_G0033734
 protein coding gene Chr8:90975303-90982655 (+)
LP/J MGP_LPJ_G0033879
 protein coding gene Chr8:96444361-96451233 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033776
 protein coding gene Chr8:105390785-105400024 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034486
 protein coding gene Chr8:95232190-95240228 (+)
PWK/PhJ MGP_PWKPhJ_G0032691
 protein coding gene Chr8:91392569-91399147 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032528
 protein coding gene Chr8:94077385-94084498 (+)
WSB/EiJ MGP_WSBEiJ_G0033101
 protein coding gene Chr8:95766747-95775101 (+)



Homology
more
  • Human Ortholog
    POLR2C, RNA polymerase II subunit C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLR2C, RNA polymerase II subunit C
  • Synonyms
    hRPB33, hsRPB3, RPB3, RPB31
  • Links
    NCBI Gene ID: 5432
    neXtProt AC: NX_P19387
    UniProt: P19387

  • Chr Location
    16q21; chr16:57462660-57472009 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    104
  • cDNA Data
    116
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20021 NCBI Gene Model | MGI Sequence Detail 6793 C57BL/6J ±  kb
transcript NM_009090 RefSeq | MGI Sequence Detail 1580 C57BL/6  
polypeptide P97760 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012989 DNA-directed RNA polymerase II subunit RPB3
    (term hierarchy)
  • InterPro Domains
    IPR050518 Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit
    IPR001514 DNA-directed RNA polymerase, 30-40kDa subunit, conserved site
    IPR011262 DNA-directed RNA polymerase, insert domain
    IPR036643 DNA-directed RNA polymerase, insert domain superfamily
    IPR011263 DNA-directed RNA polymerase, RpoA/D/Rpb3-type
    IPR022842 DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1
    IPR036603 RNA polymerase, RBP11-like subunit
Molecular
Reagents
less
  • All nucleic 119
    Genomic 2
    cDNA 117

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-38344
References
more
  • Summaries
    All 32
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:38275 Korobko IV, et al., Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31. Gene. 1997 Jan 31;185(1):1-4
  • Latest
    J:238190 Alldred MJ, et al., Expression profile analysis of vulnerable CA1 pyramidal neurons in young-Middle-Aged Ts65Dn mice. J Comp Neurol. 2015 Jan 01;523(1):61-74
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory