Papola MGI Mouse Gene Detail - MGI:109301 - poly (A) polymerase alpha

Symbol

Papola
Name

poly (A) polymerase alpha
Synonyms

PapIII, Plap

Feature Type

protein coding gene
IDs

MGI:109301
NCBI Gene: 18789
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr12:105750953-105805203 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 56.06 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

1106 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109301	protein coding gene	Chr12:105750926-105805208 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020096	protein coding gene	Chr12:107684779-107738931 (+)
A/J	MGP_AJ_G0020050	protein coding gene	Chr12:103656833-103715616 (+)
AKR/J	MGP_AKRJ_G0020026	protein coding gene	Chr12:106660818-106714930 (+)
BALB/cJ	MGP_BALBcJ_G0020036	protein coding gene	Chr12:104069373-104124589 (+)
C3H/HeJ	MGP_C3HHeJ_G0019838	protein coding gene	Chr12:107097553-107153230 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020481	protein coding gene	Chr12:110998538-111054871 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018093	protein coding gene	Chr12:100247374-100300840 (+)
CAST/EiJ	MGP_CASTEiJ_G0019380	protein coding gene	Chr12:101903178-101958165 (+)
CBA/J	MGP_CBAJ_G0019805	protein coding gene	Chr12:115415072-115471504 (+)
DBA/2J	MGP_DBA2J_G0019922	protein coding gene	Chr12:103181271-103236290 (+)
FVB/NJ	MGP_FVBNJ_G0019907	protein coding gene	Chr12:101962665-102017547 (+)
LP/J	MGP_LPJ_G0019997	protein coding gene	Chr12:107573844-107629808 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019945	protein coding gene	Chr12:118799200-118854575 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020510	protein coding gene	Chr12:106059629-106115535 (+)
PWK/PhJ	MGP_PWKPhJ_G0019139	protein coding gene	Chr12:97764970-97820008 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018943	protein coding gene	Chr12:100276529-100335114 (+)
WSB/EiJ	MGP_WSBEiJ_G0019437	protein coding gene	Chr12:107008863-107066248 (+)

Human Ortholog

PAPOLA, poly(A) polymerase alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PAPOLA, poly(A) polymerase alpha
Synonyms

PAP, PAP-alpha
Links

HGNC:14981

NCBI Gene ID: 10914

neXtProt AC: NX_P51003

UniProt: P51003
Chr Location

14q32.2; chr14:96501433-96567116 (+) GRCh38

MGI Vertebrate Homology

Papola stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PAPOLA
Protein SuperFamily

PolyA_polymerase
Gene Tree

Papola

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

194
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

190
Targeted

1
Genomic Mutations

1 involving Papola
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

65 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

102
cDNA Data

23
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase papola

ZFIN papola

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All Sequences

121
RefSeq

32
UniProt

14
CCDS

CCDS49163.1, CCDS84000.1

Ensembl

ENSMUSG00000021111 (Evidence)
NCBI Gene

18789

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021111	Ensembl Gene Model \| MGI Sequence Detail	54251	C57BL/6J	± kb
transcript	ENSMUST00000109901	Ensembl \| MGI Sequence Detail	4380	Not Applicable
polypeptide	ENSMUSP00000105527	Ensembl \| MGI Sequence Detail	739	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000012267 poly(A) polymerase alpha

(term hierarchy)
EC

2.7.7.19
InterPro Domains

IPR011068 Nucleotidyltransferase, class I-like, C-terminal

IPR043519 Nucleotidyltransferase superfamily

IPR014492 Poly(A) polymerase

IPR007012 Poly(A) polymerase, central domain

IPR048840 Poly(A) polymerase, nucleotidyltransferase domain

IPR007010 Poly(A) polymerase, RNA-binding domain
GlyGen

Q61183 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 26

Genomic 1

cDNA 24

Other 1

Microarray probesets 7

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MGD-MRK-38346

Summaries

All 44

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 14
Earliest

J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Papola:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114922	Chr12:105750954-105751002 (+)	25 bp
Tssr114923	Chr12:105803490-105803513 (+)	52,549 bp
Tssr114924	Chr12:105803671-105803720 (+)	52,743 bp
Tssr114925	Chr12:105804249-105804266 (+)	53,305 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24