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Mmp15 Gene Detail
Summary
  • Symbol
    Mmp15
  • Name
    matrix metallopeptidase 15
  • Synonyms
    Membrane type 2-MMP, MT2-MMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:109320
    NCBI Gene: 17388
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:96078924-96100921 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 47.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109320
 protein coding gene Chr8:96078896-96101708 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033985
 protein coding gene Chr8:96833731-96857207 (+)
A/J MGP_AJ_G0033968
 protein coding gene Chr8:93045233-93067264 (+)
AKR/J MGP_AKRJ_G0033894
 protein coding gene Chr8:95574235-95596280 (+)
BALB/cJ MGP_BALBcJ_G0033960
 protein coding gene Chr8:93127432-93149734 (+)
C3H/HeJ MGP_C3HHeJ_G0033670
 protein coding gene Chr8:96303591-96325620 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034481
 protein coding gene Chr8:100364945-100389970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031422
 protein coding gene Chr8:86843211-86866460 (+)
CAST/EiJ MGP_CASTEiJ_G0033002
 protein coding gene Chr8:95894317-95918220 (+)
CBA/J MGP_CBAJ_G0033646
 protein coding gene Chr8:103652164-103674193 (+)
DBA/2J MGP_DBA2J_G0033800
 protein coding gene Chr8:92529435-92552439 (+)
FVB/NJ MGP_FVBNJ_G0033747
 protein coding gene Chr8:91478003-91500411 (+)
LP/J MGP_LPJ_G0033892
 protein coding gene Chr8:96966759-96988863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033789
 protein coding gene Chr8:105906833-105928841 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034499
 protein coding gene Chr8:95751005-95772985 (+)
PWK/PhJ MGP_PWKPhJ_G0032704
 protein coding gene Chr8:91891293-91913467 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032541
 protein coding gene Chr8:94609388-94634773 (+)
WSB/EiJ MGP_WSBEiJ_G0033114
 protein coding gene Chr8:96275726-96297746 (+)



Homology
more
  • Human Ortholog
    MMP15, matrix metallopeptidase 15
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP15, matrix metallopeptidase 15
  • Synonyms
    MMP-15, MT2-MMP, MT2MMP, MTMMP2, SMCP-2
  • Links
    NCBI Gene ID: 4324
    neXtProt AC: NX_P51511
    UniProt: P51511

  • Chr Location
    16q21; chr16:58025754-58046901 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    880
  • Tissues
    133
  • cDNA Data
    76
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17388 NCBI Gene Model | MGI Sequence Detail 21998 C57BL/6J ±  kb
    transcript NM_008609 RefSeq | MGI Sequence Detail 4335 ZRU/MplStud  
    polypeptide O54732 UniProt | EBI | MGI Sequence Detail 657 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 84
      cDNA 78
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38365, MGI:2142576
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 17
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:38322 Itoh S, et al., Isolation of a promoter region in mouse cytochrome P450 3A (Cyp3A16) gene and its transcriptional control. Biochim Biophys Acta. 1997 Feb 7;1350(2):155-8
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory