Eya2 MGI Mouse Gene Detail - MGI:109341 - EYA transcriptional coactivator and phosphatase 2

Symbol

Eya2
Name

EYA transcriptional coactivator and phosphatase 2

Feature Type

protein coding gene
IDs

MGI:109341
NCBI Gene: 14049
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:165436952-165613647 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.83 cM
Mapping Data

8 experiments

SNPs within 2kb

5331 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109341	protein coding gene	Chr2:165436892-165613647 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026897	protein coding gene	Chr2:171163315-171346589 (+)
A/J	MGP_AJ_G0026863	protein coding gene	Chr2:164151539-164331078 (+)
AKR/J	MGP_AKRJ_G0026836	protein coding gene	Chr2:169050235-169227964 (+)
BALB/cJ	MGP_BALBcJ_G0026872	protein coding gene	Chr2:164511528-164689919 (+)
C3H/HeJ	MGP_C3HHeJ_G0026616	protein coding gene	Chr2:169389298-169583466 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027320	protein coding gene	Chr2:176124596-176323008 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024692	protein coding gene	Chr2:157546512-157717484 (+)
CAST/EiJ	MGP_CASTEiJ_G0026074	protein coding gene	Chr2:169886584-170012245 (+)
CBA/J	MGP_CBAJ_G0026593	protein coding gene	Chr2:182524035-182751783 (+)
DBA/2J	MGP_DBA2J_G0026729	protein coding gene	Chr2:163308680-163485723 (+)
FVB/NJ	MGP_FVBNJ_G0026697	protein coding gene	Chr2:161754096-161946779 (+)
LP/J	MGP_LPJ_G0026831	protein coding gene	Chr2:171206065-171383767 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026716	protein coding gene	Chr2:186054800-186244290 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027376	protein coding gene	Chr2:168943128-169122540 (+)
PWK/PhJ	MGP_PWKPhJ_G0025809	protein coding gene	Chr2:162918356-163095387 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025611	protein coding gene	Chr2:167855691-168042004 (+)
WSB/EiJ	MGP_WSBEiJ_G0026145	protein coding gene	Chr2:169829562-170025672 (+)

Human Ortholog

EYA2, EYA transcriptional coactivator and phosphatase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EYA2, EYA transcriptional coactivator and phosphatase 2
Synonyms

EAB1
Links

HGNC:3520

NCBI Gene ID: 2139

neXtProt AC: NX_O00167

UniProt: O00167
Chr Location

20q13.12; chr20:46894624-47188844 (+) GRCh38

MGI Vertebrate Homology

Eya2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EYA2
Gene Tree

Eya2

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Phenotype Summary

10 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit mild hearing loss and small thymus.

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All GO Annotations

25
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1146
Tissues

203
cDNA Data

59
Literature Summary

35

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EYA2

Xenbase eya2

ZFIN eya2

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All Sequences

56
RefSeq

10
UniProt

5
CCDS

CCDS17084.1

Ensembl

ENSMUSG00000017897 (Evidence)
NCBI Gene

14049

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017897	Ensembl Gene Model \| MGI Sequence Detail	176696	C57BL/6J	± kb
transcript	ENSMUST00000088132	Ensembl \| MGI Sequence Detail	2447	Not Applicable
polypeptide	ENSMUSP00000085455	Ensembl \| MGI Sequence Detail	532	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007274 eyes absent homolog 2

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR006545 EYA domain

IPR042577 EYA domain, metazoan

IPR038102 EYA domain superfamily

IPR028472 Eyes absent family

IPR036412 HAD-like superfamily

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All nucleic 65

cDNA 60

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-38386, MGI:2138916

Summaries

All 71

Developmental Gene Expression 35

Gene Ontology 11

Phenotypes 7
Earliest

J:38379 Xu PX, et al., Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode. Development. 1997 Jan;124(1):219-31
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Eya2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21727	Chr2:165436929-165437000 (+)	13 bp
Tssr21728	Chr2:165438091-165438092 (+)	1,140 bp
Tssr21729	Chr2:165443710-165443755 (+)	6,781 bp
Tssr21730	Chr2:165497157-165497237 (+)	60,245 bp
Tssr21731	Chr2:165497240-165497271 (+)	60,304 bp
Tssr21732	Chr2:165572004-165572016 (+)	135,058 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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