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Ucp2 Gene Detail
Summary
  • Symbol
    Ucp2
  • Name
    uncoupling protein 2 (mitochondrial, proton carrier)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109354
    NCBI Gene: 22228
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100142565-100148832 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109354
 protein coding gene Chr7:100142544-100151227 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032570
 protein coding gene Chr7:103377076-103385742 (+)
A/J MGP_AJ_G0032544
 protein coding gene Chr7:100776325-100784991 (+)
AKR/J MGP_AKRJ_G0032480
 protein coding gene Chr7:103175941-103184607 (+)
BALB/cJ MGP_BALBcJ_G0032555
 protein coding gene Chr7:100452756-100461422 (+)
C3H/HeJ MGP_C3HHeJ_G0032270
 protein coding gene Chr7:103553933-103562587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033053
 protein coding gene Chr7:107303753-107312436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030047
 protein coding gene Chr7:103179180-103188584 (+)
CAST/EiJ MGP_CASTEiJ_G0031597
 protein coding gene Chr7:95101444-95111120 (+)
CBA/J MGP_CBAJ_G0032237
 protein coding gene Chr7:110981405-110990094 (+)
DBA/2J MGP_DBA2J_G0032388
 protein coding gene Chr7:99109641-99118321 (+)
FVB/NJ MGP_FVBNJ_G0032345
 protein coding gene Chr7:98893763-98902429 (+)
LP/J MGP_LPJ_G0032478
 protein coding gene Chr7:104729094-104737760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032378
 protein coding gene Chr7:112412444-112421131 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033075
 protein coding gene Chr7:102441479-102450166 (+)
PWK/PhJ MGP_PWKPhJ_G0031315
 protein coding gene Chr7:92216738-92227042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031158
 protein coding gene Chr7:89752042-89760715 (+)
WSB/EiJ MGP_WSBEiJ_G0031714
 protein coding gene Chr7:103140995-103149678 (+)



Homology
more
  • Human Ortholog
    UCP2, uncoupling protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UCP2, uncoupling protein 2
  • Synonyms
    BMIQ4, SLC25A8, UCPH
  • Links
    NCBI Gene ID: 7351
    neXtProt AC: NX_P55851
    UniProt: P55851

  • Chr Location
    11q13.4; chr11:73974672-73983202 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ucp2 mouse models; 5 with human UCP2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 7 genetic backgrounds
    6 phenotypes from multigenic genotypes
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    952
  • Tissues
    149
  • cDNA Data
    19
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22228 NCBI Gene Model | MGI Sequence Detail 6268 C57BL/6J ±  kb
    transcript NR_184451 RefSeq | MGI Sequence Detail 1739 ZRU/MplStud  
    polypeptide P70406 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 2
      cDNA 22
      Primer pair 10
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38399
    References
    more
    • Summaries
      All 236
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 16
      Phenotypes 115
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345820 Cardarelli S, et al., Modulation of cAMP/cGMP signaling as prevention of congenital heart defects in Pde2A deficient embryos: a matter of oxidative stress. Cell Death Dis. 2024 Feb 23;15(2):169
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory