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Lmo4 Gene Detail
Summary
  • Symbol
    Lmo4
  • Name
    LIM domain only 4
  • Synonyms
    A730077C12Rik, Crp3, Etohi4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109360
    NCBI Gene: 16911
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:143894291-143910981 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 68.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    307 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109360
 protein coding gene Chr3:143894291-143911016 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027949
 protein coding gene Chr3:147467696-147485590 (-)
A/J MGP_AJ_G0027906
 protein coding gene Chr3:142250843-142267496 (-)
AKR/J MGP_AKRJ_G0027872
 protein coding gene Chr3:146043705-146062914 (-)
BALB/cJ MGP_BALBcJ_G0027918
 protein coding gene Chr3:142046228-142063776 (-)
C3H/HeJ MGP_C3HHeJ_G0027648
 protein coding gene Chr3:146357803-146374812 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028362
 protein coding gene Chr3:152555502-152574574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025700
 protein coding gene Chr3:137397982-137414748 (-)
CAST/EiJ MGP_CASTEiJ_G0027104
 protein coding gene Chr3:146319830-146337960 (-)
CBA/J MGP_CBAJ_G0027625
 protein coding gene Chr3:157800683-157817307 (-)
DBA/2J MGP_DBA2J_G0027764
 protein coding gene Chr3:141412697-141429664 (-)
FVB/NJ MGP_FVBNJ_G0027731
 protein coding gene Chr3:138809022-138825845 (-)
LP/J MGP_LPJ_G0027874
 protein coding gene Chr3:148888468-148905821 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027763
 protein coding gene Chr3:166149998-166168360 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028420
 protein coding gene Chr3:145651969-145668644 (-)
PWK/PhJ MGP_PWKPhJ_G0026828
 protein coding gene Chr3:141223714-141240716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026655
 protein coding gene Chr3:143804025-143821600 (-)
WSB/EiJ MGP_WSBEiJ_G0027183
 protein coding gene Chr3:146543064-146560494 (-)



Homology
more
  • Human Ortholog
    LMO4, LIM domain only 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMO4, LIM domain only 4
  • Links
    NCBI Gene ID: 8543
    neXtProt AC: NX_P61968
    UniProt: P61968

  • Chr Location
    1p22.3; chr1:87328880-87348923 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lmo4 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 11 alleles in 8 genetic backgrounds
    11 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die embryonically and exhibit a failure of neural tube closure and exencephaly, which is associated with abnormal patterns of cell proliferation and with high levels of apoptosis within the neuroepithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1388
  • Tissues
    365
  • cDNA Data
    186
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028266 Ensembl Gene Model | MGI Sequence Detail 16691 C57BL/6J ±  kb
    transcript ENSMUST00000121796 Ensembl | MGI Sequence Detail 1417 Not Applicable  
    polypeptide ENSMUSP00000113513 Ensembl | MGI Sequence Detail 165 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 199
      cDNA 189
      Primer pair 1
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38405, MGI:1261430, MGI:2443844
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 110
      Diseases 2
      Gene Ontology 13
      Phenotypes 45
    • Earliest
      J:44447 Baumeister A, et al., Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis. J Cell Biol. 1997 Dec 1;139(5):1231-42
    • Latest
      J:344238 Zheng Y, et al., Histone methylation mediated by NSD1 is required for the establishment and maintenance of neuronal identities. Cell Rep. 2023 Dec 26;42(12):113496
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory