Krt86 MGI Mouse Gene Detail - MGI:109362

Symbol

Krt86
Name

keratin 86
Synonyms

Khb4, Krt2-10, Krt2-11, MHb4

Feature Type

protein coding gene
IDs

MGI:109362
NCBI Gene: 16679
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr15:101371359-101377864 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.90 cM
Mapping Data

2 experiments

SNPs within 2kb

245 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109362	protein coding gene	Chr15:101371359-101377867 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022375	protein coding gene	Chr15:103544698-103555413 (+)
A/J	MGP_AJ_G0022337	protein coding gene	Chr15:99442089-99449676 (+)
AKR/J	MGP_AKRJ_G0022313	protein coding gene	Chr15:102471694-102478867 (+)
BALB/cJ	MGP_BALBcJ_G0022341	protein coding gene	Chr15:99547042-99553687 (+)
C3H/HeJ	MGP_C3HHeJ_G0022110	protein coding gene	Chr15:102562074-102572641 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022789	protein coding gene	Chr15:107406017-107416698 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020314	protein coding gene	Chr15:95172233-95178697 (+)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0022080	protein coding gene	Chr15:111132161-111151355 (+)
DBA/2J	MGP_DBA2J_G0022207	protein coding gene	Chr15:98778560-98785148 (+)
FVB/NJ	MGP_FVBNJ_G0022186	protein coding gene	Chr15:97831478-97840370 (+)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0022207	protein coding gene	Chr15:114795752-114802998 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022803	protein coding gene	Chr15:102509733-102521598 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0021207	protein coding gene	Chr15:102400438-102407924 (+)
WSB/EiJ	MGP_WSBEiJ_G0021685	protein coding gene	Chr15:103148051-103161051 (+)

Human Ortholog

KRT86, keratin 86

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT86, keratin 86
Synonyms

Hb1, HB6, K86, KRTHB1, KRTHB6, MNX
Links

HGNC:6463

NCBI Gene ID: 3892

neXtProt AC: NX_O43790

UniProt: O43790
Chr Location

12q13.13; chr12:52249300-52309163 (+) GRCh38

MGI Vertebrate Homology

Krt86 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT86
Gene Tree

Krt86

Diseases

4 with human KRT81,KRT83,KRT86 associations

				Human Disease	Mouse Models
				breast cancer IDs breast cancer DOID:1612 DOID:1648 DOID:4241 ICD10CM:C50 ICD9CM:174.8 MESH:D001943 NCI:C9335 OMIM:114480 UMLS_CUI:C0006142
				erythrokeratodermia variabilis et progressiva 5 IDs erythrokeratodermia variabilis et progressiva 5 DOID:0080251 OMIM:617756
				hair disease IDs hair disease DOID:421 MESH:D006201 NCI:C34656 UMLS_CUI:C0018500
				monilethrix IDs monilethrix DOID:0050472 ICD10CM:Q84.1 MESH:D056734 NCI:C84894 OMIM:158000 UMLS_CUI:C0546966

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

1
Genomic Mutations

4 involving Krt86
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

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All GO Annotations

6
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

3
cDNA Data

6
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

3
CCDS

CCDS37218.1

Ensembl

ENSMUSG00000067614 (Evidence)
NCBI Gene

16679

			Length	Strain/Species	Flank
genomic	16679	NCBI Gene Model \| MGI Sequence Detail	6506	C57BL/6J	± kb
transcript	NM_010667	RefSeq \| MGI Sequence Detail	1960	ZRU/MplStud
polypeptide	P97861	UniProt \| EBI \| MGI Sequence Detail	486	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head

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All nucleic 19

Genomic 9

cDNA 10

Microarray probesets 3

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MGD-MRK-38407, MGI:2145983

Summaries

All 59

Developmental Gene Expression 3

Diseases 1

Gene Ontology 3

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Krt86:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133302	Chr15:101371353-101371359 (+)	-3 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24