Hp1bp3 MGI Mouse Gene Detail - MGI:109369 - heterochromatin protein 1, binding protein 3

Symbol

Hp1bp3
Name

heterochromatin protein 1, binding protein 3
Synonyms

Hp1bp74, MGC:28927

Feature Type

protein coding gene
IDs

MGI:109369
NCBI Gene: 15441
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:137943781-137971994 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 70.03 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

835 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109369	protein coding gene	Chr4:137943607-137971994 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028990	protein coding gene	Chr4:140929363-140960225 (+)
A/J	MGP_AJ_G0028949	protein coding gene	Chr4:134914853-134943181 (+)
AKR/J	MGP_AKRJ_G0028901	protein coding gene	Chr4:138764564-138793080 (+)
BALB/cJ	MGP_BALBcJ_G0028973	protein coding gene	Chr4:135585565-135615440 (+)
C3H/HeJ	MGP_C3HHeJ_G0028687	protein coding gene	Chr4:139112950-139152461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029414	protein coding gene	Chr4:145939411-145968542 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026685	protein coding gene	Chr4:127898574-127927094 (+)
CAST/EiJ	MGP_CASTEiJ_G0028119	protein coding gene	Chr4:137274909-137306662 (+)
CBA/J	MGP_CBAJ_G0028652	protein coding gene	Chr4:150086565-150118222 (+)
DBA/2J	MGP_DBA2J_G0028801	protein coding gene	Chr4:135289351-135317748 (+)
FVB/NJ	MGP_FVBNJ_G0028768	protein coding gene	Chr4:134313481-134341639 (+)
LP/J	MGP_LPJ_G0028900	protein coding gene	Chr4:141019140-141047769 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028794	protein coding gene	Chr4:154111232-154142720 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029452	protein coding gene	Chr4:139273745-139302143 (+)
PWK/PhJ	MGP_PWKPhJ_G0027839	protein coding gene	Chr4:132133482-132167096 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027665	protein coding gene	Chr4:135051045-135079001 (+)
WSB/EiJ	MGP_WSBEiJ_G0028197	protein coding gene	Chr4:139503318-139535065 (+)

Human Ortholog

HP1BP3, heterochromatin protein 1 binding protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HP1BP3, heterochromatin protein 1 binding protein 3
Synonyms

HP1-BP74, HP1BP74
Links

HGNC:24973

NCBI Gene ID: 50809

neXtProt AC: NX_Q5SSJ5

UniProt: Q5SSJ5
Chr Location

1p36.12; chr1:20740266-20787323 (-) GRCh38

MGI Vertebrate Homology

Hp1bp3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HP1BP3
Gene Tree

Hp1bp3

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

23
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Hp1bp3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit postnatal lethality and reduced body weight.

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All GO Annotations

27
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

20
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hp1bp3

ZFIN hp1bp3

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All Sequences

133
RefSeq

48
UniProt

9
CCDS

CCDS38927.1, CCDS51334.1

Ensembl

ENSMUSG00000028759 (Evidence)
NCBI Gene

15441

			Length	Strain/Species	Flank
genomic	15441	NCBI Gene Model \| MGI Sequence Detail	28214	C57BL/6J	± kb
transcript	NR_185235	RefSeq \| MGI Sequence Detail	4996	C57BL/6
polypeptide	Q3TEA8	UniProt \| EBI \| MGI Sequence Detail	554	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000008726 heterochromatin protein 1-binding protein 3

(term hierarchy)
InterPro Domains

IPR005819 Linker histone H1/H5

IPR005818 Linker histone H1/H5, domain H15

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q3TEA8 1 site, 1 O-linked glycan (1 site)

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All nucleic 20

cDNA 20

Microarray probesets 3

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MGD-MRK-38414

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 17
Earliest

J:37212 Le Douarin B, et al., A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors. EMBO J. 1996 Dec 2;15(23):6701-15
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Hp1bp3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39835	Chr4:137943610-137943635 (+)	-158 bp
Tssr39836	Chr4:137943722-137943775 (+)	-32 bp
Tssr39837	Chr4:137943776-137943814 (+)	14 bp
Tssr39838	Chr4:137943935-137943961 (+)	167 bp
Tssr39839	Chr4:137944431-137944514 (+)	692 bp
Tssr39840	Chr4:137944546-137944621 (+)	803 bp
Tssr39841	Chr4:137948885-137948940 (+)	5,132 bp
Tssr39842	Chr4:137953360-137953361 (+)	9,580 bp
Tssr39843	Chr4:137966910-137966929 (+)	23,139 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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