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Atf3 Gene Detail
Summary
  • Symbol
    Atf3
  • Name
    activating transcription factor 3
  • Synonyms
    LRG-21
  • Feature Type
    protein coding gene
  • IDs
    MGI:109384
    NCBI Gene: 11910
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:190902493-190915530 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 96.28 cM, cytoband H6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109384
 protein coding gene Chr1:190902493-190950236 (-)
129S1/SvImJ ENSMUSG00200003563
 protein coding gene Chr1:188680715-188728469 (-)
A/J ENSMUSG00195008070
 protein coding gene Chr1:188260316-188308085 (-)
AKR/J ENSMUSG00220004562
 protein coding gene Chr1:187504170-187551934 (-)
BALB/cJ ENSMUSG00180016725
 protein coding gene Chr1:188325773-188373535 (-)
C3H/HeJ ENSMUSG00175021639
 protein coding gene Chr1:188513745-188561519 (-)
C57BL/6NJ ENSMUSG00215013175
 protein coding gene Chr1:187735279-187783027 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015048
 protein coding gene Chr1:180967378-181016824 (-)
CAST/EiJ ENSTCUG00005002094
 protein coding gene Chr1:186295872-186351214 (-)
CBA/J ENSMUSG00210003367
 protein coding gene Chr1:188175785-188223543 (-)
DBA/2J ENSMUSG00185009964
 protein coding gene Chr1:192789043-192836806 (-)
FVB/NJ ENSMUSG00205003993
 protein coding gene Chr1:187171791-187219574 (-)
JF1/MsJ ENSUMUG00000002989
 protein coding gene Chr1:191779875-191829325 (-)
LP/J ENSMUSG00230021482
 protein coding gene Chr1:192324656-192372420 (-)
NOD/ShiLtJ ENSMUSG00190028991
 protein coding gene Chr1:188159291-188207054 (-)
NZO/HlLtJ ENSMUSG00225015761
 protein coding gene Chr1:196085962-196133724 (-)
PWK/PhJ ENSLUMG00010006055
 protein coding gene Chr1:187008018-187055778 (-)
SPRET/EiJ ENSMSPG00010023101
 protein coding gene Chr1:190550197-190599401 (-)
WSB/EiJ ENSIUOG00005004381
 protein coding gene Chr1:187509486-187557220 (-)



Homology
more
  • Human Ortholog
    ATF3, activating transcription factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF3, activating transcription factor 3
  • Links
    NCBI Gene ID: 467
    UniProt: P18847

  • Chr Location
    1q32.3; chr1:212565334-212620777 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 4 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    113 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display enhanced allergen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine and Th2 cytokine responses in lung tissue and lung-derived CD4+ lymphocytes. Primary pancreatic islets are partially protected from cytokine- or nitric oxide-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    76
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    223
  • cDNA Data
    33
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11910 NCBI Gene Model | MGI Sequence Detail 13038 C57BL/6J ±  kb
    transcript NM_007498 RefSeq | MGI Sequence Detail 1981 ZRU/MplStud  
    polypeptide Q60765 UniProt | EBI | MGI Sequence Detail 181 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 33
      Primer pair 8
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38429
    References
    more
    • Summaries
      All 257
      Developmental Gene Expression 31
      Gene Ontology 17
      Phenotypes 113
    • Earliest
      J:40530 Hai TW, et al., Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers [published erratum appears in Genes Dev 1990 Apr;4(4):682]. Genes Dev. 1989 Dec;3(12B):2083-90
    • Latest
      J:391224 Roger A, et al., Sensory neuron production of substance P and TAFA4 promotes disease tolerance during viral infection. Immunity. 2026 Mar 10;59(3):682-699.e8
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory