Commd1 MGI Mouse Gene Detail - MGI:109474

Symbol

Commd1
Name

COMM domain containing 1
Synonyms

Murr1

Feature Type

protein coding gene
IDs

MGI:109474
NCBI Gene: 17846
Alliance

gene page

Sequence Map

Chr11:22849728-22934539 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 14.22 cM
Mapping Data

5 experiments

SNPs within 2kb

2126 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109474	protein coding gene	Chr11:22846136-22934539 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018081	protein coding gene	Chr11:20604839-20693475 (-)
A/J	MGP_AJ_G0018054	protein coding gene	Chr11:19820575-19907482 (-)
AKR/J	MGP_AKRJ_G0018018	protein coding gene	Chr11:20527028-20618246 (-)
BALB/cJ	MGP_BALBcJ_G0018022	protein coding gene	Chr11:19956469-20042866 (-)
C3H/HeJ	MGP_C3HHeJ_G0017836	protein coding gene	Chr11:20406960-20496194 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018474	protein coding gene	Chr11:21459610-21551931 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016132	protein coding gene	Chr11:18718241-18807342 (-)
CAST/EiJ	MGP_CASTEiJ_G0017397	protein coding gene	Chr11:20460011-20548193 (-)
CBA/J	MGP_CBAJ_G0017810	protein coding gene	Chr11:22411141-22505025 (-)
DBA/2J	MGP_DBA2J_G0017920	protein coding gene	Chr11:19751447-19837870 (-)
FVB/NJ	MGP_FVBNJ_G0017912	protein coding gene	Chr11:19524763-19613942 (-)
LP/J	MGP_LPJ_G0017991	protein coding gene	Chr11:20718730-20810614 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017938	protein coding gene	Chr11:22888370-22980363 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018515	protein coding gene	Chr11:20639421-20729177 (-)
PWK/PhJ	MGP_PWKPhJ_G0017178	protein coding gene	Chr11:19788864-19871877 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016975	protein coding gene	Chr11:20373731-20469126 (-)
WSB/EiJ	MGP_WSBEiJ_G0017451	protein coding gene	Chr11:20264427-20353120 (-)

Human Ortholog

COMMD1, copper metabolism domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

COMMD1, copper metabolism domain containing 1
Synonyms

C2orf5, MURR1
Links

HGNC:23024

NCBI Gene ID: 150684

neXtProt AC: NX_Q8N668

UniProt: Q8N668
Chr Location

2p15; chr2:61888391-62147247 (+) GRCh38

MGI Vertebrate Homology

Commd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: COMMD1
Gene Tree

Commd1

less

Phenotype Summary

12 phenotypes from 2 alleles in 3 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Commd1
Incidental Mutations

APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele are embryonic lethal with growth retardation, failure to turn, increased apoptosis in brain mesenchyme and defects in extraembryonic tissue development.

less

All GO Annotations

58
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

26
cDNA Data

15
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase commd1

less

All Sequences

66
RefSeq

8
UniProt

6
CCDS

CCDS24472.1

Ensembl

ENSMUSG00000051355 (Evidence)
NCBI Gene

17846

			Length	Strain/Species	Flank
genomic	17846	NCBI Gene Model \| MGI Sequence Detail	84812	C57BL/6J	± kb
transcript	NM_001361661	RefSeq \| MGI Sequence Detail	828	ZRU/MplStud
polypeptide	Q8K4M5	UniProt \| EBI \| MGI Sequence Detail	188	Not Applicable

less

UniProt

6 Sequences
Protein Ontology

PR:000005729 COMM domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR033776 COMMD1 N-terminal domain

IPR017920 COMM domain

IPR037351 COMM domain-containing protein 1

less

All nucleic 22

Genomic 2

cDNA 16

Primer pair 3

Other 1

Microarray probesets 4

less

MGD-MRK-38519, MGI:2144104

Summaries

All 52

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 15
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:308690 Coccia E, et al., SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L. Cell Death Dis. 2020 Feb 3;11(2):82

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24