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Wnt8b Gene Detail
Summary
  • Symbol
    Wnt8b
  • Name
    wingless-type MMTV integration site family, member 8B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109485
    NCBI Gene: 22423
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:44481912-44502712 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 37.98 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    825 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109485
 protein coding gene Chr19:44481911-44502712 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025171
 protein coding gene Chr19:43989146-44012953 (+)
A/J MGP_AJ_G0025148
 protein coding gene Chr19:41883325-41905023 (+)
AKR/J MGP_AKRJ_G0025116
 protein coding gene Chr19:43230954-43254091 (+)
BALB/cJ MGP_BALBcJ_G0025142
 protein coding gene Chr19:41934142-41955185 (+)
C3H/HeJ MGP_C3HHeJ_G0024902
 protein coding gene Chr19:43386164-43408323 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025585
 protein coding gene Chr19:45071578-45094729 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022999
 protein coding gene Chr19:41157058-41177617 (+)
CAST/EiJ MGP_CASTEiJ_G0024367
 protein coding gene Chr19:43105943-43131773 (+)
CBA/J MGP_CBAJ_G0024882
 protein coding gene Chr19:47342770-47363317 (+)
DBA/2J MGP_DBA2J_G0025014
 protein coding gene Chr19:41702571-41723014 (+)
FVB/NJ MGP_FVBNJ_G0024975
 protein coding gene Chr19:41472621-41492849 (+)
LP/J MGP_LPJ_G0025100
 protein coding gene Chr19:43927555-43951227 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025006
 protein coding gene Chr19:46780079-46802520 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025643
 protein coding gene Chr19:43301547-43324508 (+)
PWK/PhJ MGP_PWKPhJ_G0024116
 protein coding gene Chr19:41596624-41618141 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023920
 protein coding gene Chr19:41993470-42013792 (+)
WSB/EiJ MGP_WSBEiJ_G0024437
 protein coding gene Chr19:43428093-43452276 (+)



Homology
more
  • Human Ortholog
    WNT8B, Wnt family member 8B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WNT8B, Wnt family member 8B
  • Links
    NCBI Gene ID: 7479
    neXtProt AC: NX_Q93098
    UniProt: Q93098

  • Chr Location
    10q24.31; chr10:100463009-100483744 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human WNT8B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Mice homozygous for a null allele are viable and healthy with no evidence of hippocampal or hypothalamic defects and normal cell proliferation in the neurogenic region of the adult dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1137
  • Tissues
    343
  • cDNA Data
    23
  • Literature Summary
    130
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22423 NCBI Gene Model | MGI Sequence Detail 20801 C57BL/6J ±  kb
transcript NM_011720 RefSeq | MGI Sequence Detail 3375 ZRU/MplStud  
polypeptide Q9WUD6 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 26
    Primer pair 14
    Other 11

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-39484
References
more
  • Summaries
    All 158
    Developmental Gene Expression 130
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
  • Latest
    J:341689 Zhang B, et al., KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors. Nat Commun. 2023 Oct 14;14(1):6489
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory