Snrpc MGI Mouse Gene Detail - MGI:109489 - U1 small nuclear ribonucleoprotein C

Symbol

Snrpc
Name

U1 small nuclear ribonucleoprotein C
Synonyms

Snrp1c, U1-C

Feature Type

protein coding gene
IDs

MGI:109489
NCBI Gene: 20630
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr17:28059002-28070942 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 14.59 cM, cytoband B1
Mapping Data

1 experiment

SNPs within 2kb

172 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109489	protein coding gene	Chr17:28057124-28070942 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023428	protein coding gene	Chr17:27176535-27191131 (+)
A/J	MGP_AJ_G0023386	protein coding gene	Chr17:26305631-26317784 (+)
AKR/J	MGP_AKRJ_G0023351	protein coding gene	Chr17:26483720-26497146 (+)
BALB/cJ	MGP_BALBcJ_G0023391	protein coding gene	Chr17:26579769-26591602 (+)
C3H/HeJ	MGP_C3HHeJ_G0023152	protein coding gene	Chr17:26859135-26873964 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023833	protein coding gene	Chr17:28302844-28318373 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021308	protein coding gene	Chr17:23690507-23701287 (+)
CAST/EiJ	MGP_CASTEiJ_G0022653	protein coding gene	Chr17:26830152-26851150 (+)
CBA/J	MGP_CBAJ_G0023126	protein coding gene	Chr17:29289744-29308043 (+)
DBA/2J	MGP_DBA2J_G0023257	protein coding gene	Chr17:25868871-25881058 (+)
FVB/NJ	MGP_FVBNJ_G0023227	protein coding gene	Chr17:25661396-25674654 (+)
LP/J	MGP_LPJ_G0023335	protein coding gene	Chr17:27443288-27456912 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023245	protein coding gene	Chr17:28760962-28775409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023875	protein coding gene	Chr17:26900493-26914145 (+)
PWK/PhJ	MGP_PWKPhJ_G0022403	protein coding gene	Chr17:24665330-24677784 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022221	protein coding gene	Chr17:24909491-24923518 (+)
WSB/EiJ	MGP_WSBEiJ_G0022715	protein coding gene	Chr17:26884064-26899095 (+)

Human Ortholog

SNRPC, small nuclear ribonucleoprotein polypeptide C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNRPC, small nuclear ribonucleoprotein polypeptide C
Synonyms

U1C, Yhc1
Links

HGNC:11157

NCBI Gene ID: 6631

neXtProt AC: NX_P09234

UniProt: P09234
Chr Location

6p21.31; chr6:34757505-34773857 (+) GRCh38

MGI Vertebrate Homology

Snrpc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SNRPC
Protein SuperFamily

U1_snRNP-C
Gene Tree

Snrpc

Diseases

3 with human SNRPC associations

				Human Disease	Mouse Models
				connective tissue disease IDs connective tissue disease DOID:65 MESH:D003240 NCI:C26729 UMLS_CUI:C0009782
				mixed connective tissue disease IDs mixed connective tissue disease DOID:3492 ICD10CM:M35.1 MESH:D008947 NCI:C84892 UMLS_CUI:C0026272
				systemic lupus erythematosus IDs systemic lupus erythematosus DOID:9074 ICD10CM:M32.9 ICD9CM:710.0 KEGG:05322 MESH:D008180 NCI:C3201 OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 ORDO:536 UMLS_CUI:C0024141

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

5 phenotype references

All Mutations and Alleles

27
Endonuclease-mediated

2
Gene trapped

23
Targeted

2
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available

less

All GO Annotations

22
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase snrpc

ZFIN snrpc

less

All Sequences

56
RefSeq

13
UniProt

4
CCDS

CCDS28570.1

Ensembl

ENSMUSG00000024217 (Evidence)
NCBI Gene

20630

			Length	Strain/Species	Flank
genomic	20630	NCBI Gene Model \| MGI Sequence Detail	11941	C57BL/6J	± kb
transcript	NM_001413575	RefSeq \| MGI Sequence Detail	1104	C57BL/6
polypeptide	Q62241	UniProt \| EBI \| MGI Sequence Detail	159	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015342 U1 small nuclear ribonucleoprotein C

(term hierarchy)
InterPro Domains

IPR000690 Matrin/U1-C, C2H2-type zinc finger

IPR003604 Matrin/U1-C-like, C2H2-type zinc finger

IPR013085 U1-C, C2H2-type zinc finger

IPR017340 U1 small nuclear ribonucleoprotein C

IPR036236 Zinc finger C2H2 superfamily

less

All nucleic 11

cDNA 11

Microarray probesets 5

less

MGD-MRK-39488

Summaries

All 32

Gene Ontology 5

Phenotypes 5
Earliest

J:37896 Nelissen RL, et al., Cloning and characterization of two processed pseudogenes and the cDNA for the murine U1 snRNP-specific protein C. Gene. 1997 Jan 15;184(2):273-8
Latest

J:219795 Sun S, et al., ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat Commun. 2015;6:6171

TSS for Snrpc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143362	Chr17:28059031-28059093 (+)	60 bp
Tssr143363	Chr17:28059099-28059117 (+)	106 bp
Tssr143364	Chr17:28059130-28059151 (+)	139 bp
Tssr143365	Chr17:28059177-28059188 (+)	181 bp
Tssr143366	Chr17:28066943-28066957 (+)	7,948 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24