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Crat Gene Detail
Summary
  • Symbol
    Crat
  • Name
    carnitine acetyltransferase
  • Synonyms
    CARAT
  • Feature Type
    protein coding gene
  • IDs
    MGI:109501
    NCBI Gene: 12908
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:30290483-30305602 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 21.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    347 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109501
 protein coding gene Chr2:30290483-30305825 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025568
 protein coding gene Chr2:28625433-28642200 (-)
A/J MGP_AJ_G0025546
 protein coding gene Chr2:27486356-27502649 (-)
AKR/J MGP_AKRJ_G0025515
 protein coding gene Chr2:28420616-28435963 (-)
BALB/cJ MGP_BALBcJ_G0025542
 protein coding gene Chr2:27613236-27628598 (-)
C3H/HeJ MGP_C3HHeJ_G0025303
 protein coding gene Chr2:28351478-28366806 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025987
 protein coding gene Chr2:29566501-29581833 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023395
 protein coding gene Chr2:26263362-26278070 (-)
CAST/EiJ MGP_CASTEiJ_G0024765
 protein coding gene Chr2:28250833-28266186 (-)
CBA/J MGP_CBAJ_G0025280
 protein coding gene Chr2:30570291-30587001 (-)
DBA/2J MGP_DBA2J_G0025413
 protein coding gene Chr2:27275771-27291116 (-)
FVB/NJ MGP_FVBNJ_G0025376
 protein coding gene Chr2:27095788-27111115 (-)
LP/J MGP_LPJ_G0025499
 protein coding gene Chr2:28534169-28549532 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025406
 protein coding gene Chr2:30453395-30468734 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026045
 protein coding gene Chr2:28335233-28350570 (-)
PWK/PhJ MGP_PWKPhJ_G0024512
 protein coding gene Chr2:27116109-27131614 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024312
 protein coding gene Chr2:28454382-28471541 (-)
WSB/EiJ MGP_WSBEiJ_G0024833
 protein coding gene Chr2:28465981-28481313 (-)



Homology
more
  • Human Ortholog
    CRAT, carnitine O-acetyltransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CRAT, carnitine O-acetyltransferase
  • Synonyms
    CAT, CAT1, NBIA8
  • Links
    NCBI Gene ID: 1384
    neXtProt AC: NX_P43155
    UniProt: P43155

  • Chr Location
    9q34.11; chr9:129094142-129111189 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CRAT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with muscle specific loss of function display increased circulating glucose level, impaired glucose tolerance, insulin resistance, decreased circulating triglyceride and free fatty acid levels, increased susceptibility to diet-induced obesity and abnormal mitochondrial physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    112
  • cDNA Data
    107
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12908 NCBI Gene Model | MGI Sequence Detail 15120 C57BL/6J ±  kb
    transcript NM_001420077 RefSeq | MGI Sequence Detail 4504 ZRU/MplStud  
    polypeptide P47934 UniProt | EBI | MGI Sequence Detail 626 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 108
      cDNA 107
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-39500, MGI:2139299
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:38936 Brunner S, et al., Cloning and characterization of murine carnitine acetyltransferase: evidence for a requirement during cell cycle progression. Biochem J. 1997 Mar 1;322(Pt 2):403-10
    • Latest
      J:350294 Lasheras-Otero I, et al., The Regulators of Peroxisomal Acyl-Carnitine Shuttle CROT and CRAT Promote Metastasis in Melanoma. J Invest Dermatol. 2023 Feb;143(2):305-316.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory