Sftpb MGI Mouse Gene Detail - MGI:109516 - surfactant associated protein B

Symbol

Sftpb
Name

surfactant associated protein B
Synonyms

SF-B, Sftp-3, Sftp3, SP-B

Feature Type

protein coding gene
IDs

MGI:109516
NCBI Gene: 20388
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr6:72281594-72291354 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 32.27 cM
Mapping Data

11 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109516	protein coding gene	Chr6:72281594-72291354 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030869	protein coding gene	Chr6:72847116-72856720 (+)
A/J	MGP_AJ_G0030839	protein coding gene	Chr6:70024801-70034209 (+)
AKR/J	MGP_AKRJ_G0030768	protein coding gene	Chr6:72082427-72092091 (+)
BALB/cJ	MGP_BALBcJ_G0030850	protein coding gene	Chr6:70055005-70064992 (+)
C3H/HeJ	MGP_C3HHeJ_G0030862	protein coding gene	Chr6:112143982-112154580 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031308	protein coding gene	Chr6:74764218-74774770 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028497	protein coding gene	Chr6:69172891-69182243 (+)
CAST/EiJ	MGP_CASTEiJ_G0029958	protein coding gene	Chr6:71949335-71958753 (+)
CBA/J	MGP_CBAJ_G0030537	protein coding gene	Chr6:77804727-77816747 (+)
DBA/2J	MGP_DBA2J_G0030689	protein coding gene	Chr6:69421970-69431764 (+)
FVB/NJ	MGP_FVBNJ_G0030642	protein coding gene	Chr6:68803313-68813013 (+)
LP/J	MGP_LPJ_G0030768	protein coding gene	Chr6:72757008-72766398 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030677	protein coding gene	Chr6:81202938-81212280 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031334	protein coding gene	Chr6:71893318-71904638 (+)
PWK/PhJ	MGP_PWKPhJ_G0029674	protein coding gene	Chr6:68325294-68334761 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029502	protein coding gene	Chr6:70629002-70638493 (+)
WSB/EiJ	MGP_WSBEiJ_G0030040	protein coding gene	Chr6:72262043-72271461 (+)

Human Ortholog

SFTPB, surfactant protein B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SFTPB, surfactant protein B
Synonyms

PSP-B, SFTB3, SFTP3, SMDP1, SP-B
Links

HGNC:10801

NCBI Gene ID: 6439

neXtProt AC: NX_P07988

UniProt: P07988
Chr Location

2p11.2; chr2:85657307-85668741 (-) GRCh38

MGI Vertebrate Homology

Sftpb stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SFTPB
Gene Tree

Sftpb

Diseases

13 with human SFTPB associations

				Human Disease	Mouse Models
				adult respiratory distress syndrome IDs adult respiratory distress syndrome DOID:11394 ICD10CM:J80 MESH:D012128 NCI:C3353 UMLS_CUI:C0035222
				bronchopulmonary dysplasia IDs bronchopulmonary dysplasia DOID:11650 DOID:11651 ICD10CM:P27.1 MESH:D001997 NCI:C90599
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				interstitial lung disease IDs interstitial lung disease DOID:3082 ICD10CM:J84.9 MESH:D017563 NCI:C164315 OMIM:PS619611 UMLS_CUI:C0206062
				lung non-small cell carcinoma IDs lung non-small cell carcinoma DOID:3908 EFO:0003060 KEGG:05223 MESH:D002289 NCI:C2926 UMLS_CUI:C0007131
				lung squamous cell carcinoma IDs lung squamous cell carcinoma DOID:3907 NCI:C3493 UMLS_CUI:C0149782
				newborn respiratory distress syndrome IDs newborn respiratory distress syndrome DOID:12716 DOID:11395 DOID:13859 ICD10CM:P22.0 MESH:D006819 OMIM:267450 UMLS_CUI:C0020192
				pneumonia IDs pneumonia DOID:552 DOID:10509 DOID:11742 DOID:5871 MESH:D011014 NCI:C3333 UMLS_CUI:C0032285
				pulmonary alveolar proteinosis IDs pulmonary alveolar proteinosis DOID:12120 ICD10CM:J84.01 ICD9CM:516.0 MESH:D011649 NCI:C85037 OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370 ORDO:264675 UMLS_CUI:C0034050
				pulmonary fibrosis IDs pulmonary fibrosis DOID:3770 MESH:D011658 NCI:C26869 UMLS_CUI:C0034069
				respiratory failure IDs respiratory failure DOID:11162 DOID:11391 DOID:11392 DOID:11393 ICD10CM:J96.0 ICD9CM_2006:518.84 ICD9CM:518.81 NCI:C27043 UMLS_CUI:C0264490
				respiratory syncytial virus infectious disease IDs respiratory syncytial virus infectious disease DOID:1273 MESH:D018357 NCI:C3354 UMLS_CUI:C0035235
				toxic shock syndrome IDs toxic shock syndrome DOID:14115 ICD10CM:A48.3 ICD9CM:040.82 MESH:D012772 NCI:C35498 UMLS_CUI:C0600327

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 1 allele in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

2
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Sftpb
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Inactivation of this gene results in respiratory failure.

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All GO Annotations

13
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

995
Tissues

37
cDNA Data

14
Literature Summary

150

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sftpb

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All Sequences

40
RefSeq

4
UniProt

3
CCDS

CCDS71775.1

Ensembl

ENSMUSG00000056370 (Evidence)
NCBI Gene

20388

			Length	Strain/Species	Flank
genomic	20388	NCBI Gene Model \| MGI Sequence Detail	9761	C57BL/6J	± kb
transcript	NM_147779	RefSeq \| MGI Sequence Detail	1562	ZRU/MplStud
polypeptide	P50405	UniProt \| EBI \| MGI Sequence Detail	377	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000014773 pulmonary surfactant-associated protein B

(term hierarchy)
PDB

6VYN, 6VZ0, 6VZD, 6VZE, 6W1B, 7MBK
InterPro Domains

IPR008373 Saposin

IPR003119 Saposin A-type domain

IPR008139 Saposin B type domain

IPR008138 Saposin B type, region 2

IPR011001 Saposin-like

IPR007856 Saposin-like type B, region 1

IPR051428 Sphingolipid Activators and Surfactant Proteins
GlyGen

P50405 1 site

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All nucleic 46

Genomic 4

cDNA 18

Primer pair 15

Other 9

Microarray probesets 3

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MGD-MRK-14379, MGD-MRK-14382, MGD-MRK-39515, MGI:2141447

Summaries

All 220

Developmental Gene Expression 150

Gene Ontology 9

Phenotypes 21
Earliest

J:1959 D'Amore-Bruno MA, et al., Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA. Am J Physiol. 1992 Jan;262(1 Pt 1):L40-7
Latest

J:339854 Chen SY, et al., The Fgf9-Nolz1-Wnt2 axis regulates morphogenesis of the lung. Development. 2023 Aug 15;150(16):dev201827

TSS for Sftpb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57078	Chr6:72281287-72281298 (+)	-301 bp
Tssr57079	Chr6:72281303-72281314 (+)	-285 bp
Tssr57080	Chr6:72281576-72281607 (+)	-2 bp
Tssr57081	Chr6:72281610-72281629 (+)	26 bp
Tssr57082	Chr6:72282024-72282031 (+)	434 bp
Tssr57083	Chr6:72282052-72282072 (+)	468 bp
Tssr57084	Chr6:72282627-72282644 (+)	1,042 bp
Tssr57085	Chr6:72282836-72282881 (+)	1,265 bp
Tssr57086	Chr6:72282914-72282926 (+)	1,326 bp
Tssr57087	Chr6:72282951-72282961 (+)	1,362 bp
Tssr57088	Chr6:72282964-72283013 (+)	1,395 bp
Tssr57089	Chr6:72283765-72283774 (+)	2,176 bp
Tssr57090	Chr6:72283818-72283849 (+)	2,240 bp
Tssr57091	Chr6:72283892-72283911 (+)	2,308 bp
Tssr57092	Chr6:72284122-72284196 (+)	2,565 bp
Tssr57097	Chr6:72287467-72287471 (+)	5,875 bp
Tssr57098	Chr6:72287607-72287629 (+)	6,024 bp
Tssr57099	Chr6:72287691-72287730 (+)	6,117 bp
Tssr57100	Chr6:72289849-72289901 (+)	8,281 bp
Tssr57101	Chr6:72290591-72290594 (+)	8,999 bp
Tssr57102	Chr6:72290682-72290693 (+)	9,094 bp
Tssr57103	Chr6:72290773-72290779 (+)	9,182 bp
Tssr57104	Chr6:72290966-72290982 (+)	9,380 bp
Tssr57105	Chr6:72291164-72291184 (+)	9,580 bp
Tssr57106	Chr6:72291265-72291295 (+)	9,686 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24