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Trpc4 Gene Detail
Summary
  • Symbol
    Trpc4
  • Name
    transient receptor potential cation channel, subfamily C, member 4
  • Synonyms
    CCE1, STRPC4, Trp4, Trrp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109525
    NCBI Gene: 22066
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:54063456-54225892 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 25.43 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4767 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109525
 protein coding gene Chr3:54063441-54225892 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027210
 protein coding gene Chr3:52809422-52980563 (+)
A/J MGP_AJ_G0027170
 protein coding gene Chr3:51192887-51360234 (+)
AKR/J MGP_AKRJ_G0027140
 protein coding gene Chr3:52238025-52409995 (+)
BALB/cJ MGP_BALBcJ_G0027183
 protein coding gene Chr3:51045783-51217339 (+)
C3H/HeJ MGP_C3HHeJ_G0026926
 protein coding gene Chr3:52464988-52637754 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027629
 protein coding gene Chr3:54844721-55027632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024988
 protein coding gene Chr3:47736710-47898451 (+)
CAST/EiJ MGP_CASTEiJ_G0026378
 protein coding gene Chr3:52575246-52750247 (+)
CBA/J MGP_CBAJ_G0026902
 protein coding gene Chr3:56582657-56765594 (+)
DBA/2J MGP_DBA2J_G0027036
 protein coding gene Chr3:50761267-50929611 (+)
FVB/NJ MGP_FVBNJ_G0027004
 protein coding gene Chr3:49739766-49904511 (+)
LP/J MGP_LPJ_G0027148
 protein coding gene Chr3:53521858-53697277 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027022
 protein coding gene Chr3:60698672-60887602 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027687
 protein coding gene Chr3:52146254-52324272 (+)
PWK/PhJ MGP_PWKPhJ_G0026110
 protein coding gene Chr3:50434821-50596504 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025923
 protein coding gene Chr3:51890439-52067240 (+)
WSB/EiJ MGP_WSBEiJ_G0026452
 protein coding gene Chr3:52275885-52454494 (+)



Homology
more
  • Human Ortholog
    TRPC4, transient receptor potential cation channel subfamily C member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRPC4, transient receptor potential cation channel subfamily C member 4
  • Synonyms
    HTRP-4, HTRP4, TRP4
  • Links
    NCBI Gene ID: 7223
    neXtProt AC: NX_Q9UBN4
    UniProt: Q9UBN4

  • Chr Location
    13q13.3; chr13:37632063-37869802 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TRPC4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit a significant reduction in agonist-induced Ca2+ entry and vasorelaxation of aortic rings.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    116
  • cDNA Data
    14
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027748 Ensembl Gene Model | MGI Sequence Detail 162437 C57BL/6J ±  kb
    transcript ENSMUST00000029311 Ensembl | MGI Sequence Detail 3473 Not Applicable  
    polypeptide ENSMUSP00000029311 Ensembl | MGI Sequence Detail 974 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 1
      cDNA 16
      Primer pair 8
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39524
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 16
      Phenotypes 44
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:350880 Seo JY, et al., TRPC4 deletion elicits behavioral defects in sociability by dysregulating expression of microRNA-138-2. iScience. 2024 Jan 19;27(1):108617
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory