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Btg3 Gene Detail
Summary
  • Symbol
    Btg3
  • Name
    BTG anti-proliferation factor 3
  • Synonyms
    ANA, tob5
  • Feature Type
    protein coding gene
  • IDs
    MGI:109532
    NCBI Gene: 12228
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:78156748-78174069 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 45.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    606 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109532
 protein coding gene Chr16:78129525-78174080 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022961
 protein coding gene Chr16:78519354-78537358 (-)
A/J MGP_AJ_G0022929
 protein coding gene Chr16:75060713-75077584 (-)
AKR/J MGP_AKRJ_G0022899
 protein coding gene Chr16:77315089-77331943 (-)
BALB/cJ MGP_BALBcJ_G0022931
 protein coding gene Chr16:75463399-75481607 (-)
C3H/HeJ MGP_C3HHeJ_G0022693
 protein coding gene Chr16:77759132-77780802 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023379
 protein coding gene Chr16:81054598-81068970 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020882
 protein coding gene Chr16:73488149-73507365 (-)
CAST/EiJ MGP_CASTEiJ_G0022215
 protein coding gene Chr16:78168075-78188892 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0022796
 protein coding gene Chr16:74895622-74915087 (-)
FVB/NJ MGP_FVBNJ_G0022771
 protein coding gene Chr16:74240892-74260068 (-)
LP/J MGP_LPJ_G0022865
 protein coding gene Chr16:78253650-78272768 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022790
 protein coding gene Chr16:87738586-87757229 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023396
 protein coding gene Chr16:77632546-77654757 (-)
PWK/PhJ MGP_PWKPhJ_G0021957
 protein coding gene Chr16:75102026-75119885 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021787
 protein coding gene Chr16:77320685-77343653 (-)
WSB/EiJ MGP_WSBEiJ_G0022263
 protein coding gene Chr16:77878317-77896396 (-)



Homology
more
  • Human Ortholog
    BTG3, BTG anti-proliferation factor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BTG3, BTG anti-proliferation factor 3
  • Synonyms
    ANA, ANA/BTG3, APRO4, TOB5, TOB55, TOFA
  • Links
    NCBI Gene ID: 10950
    neXtProt AC: NX_Q14201
    UniProt: Q14201

  • Chr Location
    21q21.1; chr21:17593653-17612945 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased incidence of lung tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    936
  • Tissues
    182
  • cDNA Data
    43
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12228 NCBI Gene Model | MGI Sequence Detail 17322 C57BL/6J ±  kb
    transcript NM_009770 RefSeq | MGI Sequence Detail 1414 C57BL/6  
    polypeptide P50615 UniProt | EBI | MGI Sequence Detail 252 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 1
      cDNA 44
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39531
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:38929 Guehenneux F, et al., Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle. Leukemia. 1997 Mar;11(3):370-5
    • Latest
      J:352969 Cheng YC, et al., A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis. Cell Death Differ. 2024 Aug;31(8):970-982
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory