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Bmpr2 Gene Detail
Summary
  • Symbol
    Bmpr2
  • Name
    bone morphogenetic protein receptor type 2
  • Synonyms
    2610024H22Rik, BMP-2, BMPR-II, BMPRII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095407
    NCBI Gene: 12168
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:59802721-59917240 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 30.44 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2547 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095407
 protein coding gene Chr1:59802559-59918173 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016070
 protein coding gene Chr1:59768547-59896145 (+)
A/J MGP_AJ_G0016053
 protein coding gene Chr1:57672407-57791036 (+)
AKR/J MGP_AKRJ_G0016009
 protein coding gene Chr1:59294478-59416705 (+)
BALB/cJ MGP_BALBcJ_G0016008
 protein coding gene Chr1:57700382-57818054 (+)
C3H/HeJ MGP_C3HHeJ_G0015840
 protein coding gene Chr1:59537784-59662795 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016461
 protein coding gene Chr1:62112678-62245009 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014182
 protein coding gene Chr1:53882636-53998763 (+)
CAST/EiJ MGP_CASTEiJ_G0015422
 protein coding gene Chr1:58716916-58840826 (+)
CBA/J MGP_CBAJ_G0015812
 protein coding gene Chr1:64045487-64176799 (+)
DBA/2J MGP_DBA2J_G0015913
 protein coding gene Chr1:57099432-57217359 (+)
FVB/NJ MGP_FVBNJ_G0015915
 protein coding gene Chr1:56400412-56518566 (+)
LP/J MGP_LPJ_G0015985
 protein coding gene Chr1:60655135-60775064 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015935
 protein coding gene Chr1:66963122-67085681 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016508
 protein coding gene Chr1:59200307-59319494 (+)
PWK/PhJ MGP_PWKPhJ_G0015209
 protein coding gene Chr1:56438020-56561140 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014989
 protein coding gene Chr1:58730589-58858198 (+)
WSB/EiJ MGP_WSBEiJ_G0015485
 protein coding gene Chr1:58905660-59025806 (+)



Homology
more
  • Human Ortholog
    BMPR2, bone morphogenetic protein receptor type 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMPR2, bone morphogenetic protein receptor type 2
  • Synonyms
    BMPR3, BMPR-II, BMR2, BRK-3, POVD1, PPH1, T-ALK
  • Links
    NCBI Gene ID: 659
    neXtProt AC: NX_Q13873
    UniProt: Q13873

  • Chr Location
    2q33.1-q33.2; chr2:202376327-202567751 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Bmpr2 mouse models; 4 with human BMPR2 associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 9 alleles in 12 genetic backgrounds
    44 phenotypes from multigenic genotypes
    9 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants arrest at the egg cylinder stage and die before embryonic day 9.5 with failure to form organized structure and lacking mesoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    127
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1079
  • Tissues
    202
  • cDNA Data
    23
  • Literature Summary
    77
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12168 NCBI Gene Model | MGI Sequence Detail 114520 C57BL/6J ±  kb
    transcript NM_007561 RefSeq | MGI Sequence Detail 11094 C57BL/6  
    polypeptide O35607 UniProt | EBI | MGI Sequence Detail 1038 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 9
      cDNA 23
      Primer pair 14
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916460, MGI:2138603, MGI:2138646, MGI:3034681
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 77
      Diseases 4
      Gene Ontology 29
      Phenotypes 83
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352767 Isobe S, et al., Reduced FOXF1 links unrepaired DNA damage to pulmonary arterial hypertension. Nat Commun. 2023 Nov 21;14(1):7578
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory