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Slc2a2 Gene Detail
Summary
  • Symbol
    Slc2a2
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 2
  • Synonyms
    Glut-2, Glut2, liver-type glucose transporter
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095438
    NCBI Gene: 20526
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:28752052-28782510 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 12.19 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1095438
 protein coding gene Chr3:28752052-28785508 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027116
 protein coding gene Chr3:26092755-26127290 (+)
A/J MGP_AJ_G0027076
 protein coding gene Chr3:25817973-25852122 (+)
AKR/J MGP_AKRJ_G0027045
 protein coding gene Chr3:26198136-26236662 (+)
BALB/cJ MGP_BALBcJ_G0027088
 protein coding gene Chr3:25523731-25556776 (+)
C3H/HeJ MGP_C3HHeJ_G0026829
 protein coding gene Chr3:26237679-26270567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027533
 protein coding gene Chr3:27478156-27511659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024895
 protein coding gene Chr3:23834632-23869018 (+)
CAST/EiJ MGP_CASTEiJ_G0026284
 protein coding gene Chr3:26086791-26123320 (+)
CBA/J MGP_CBAJ_G0026807
 protein coding gene Chr3:28222258-28263998 (+)
DBA/2J MGP_DBA2J_G0026941
 protein coding gene Chr3:25398993-25432160 (+)
FVB/NJ MGP_FVBNJ_G0026909
 protein coding gene Chr3:24856963-24889920 (+)
LP/J MGP_LPJ_G0027053
 protein coding gene Chr3:26785262-26819165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026930
 protein coding gene Chr3:30770491-30807243 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027593
 protein coding gene Chr3:25938731-25974082 (+)
PWK/PhJ MGP_PWKPhJ_G0026017
 protein coding gene Chr3:24878076-24912242 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025828
 protein coding gene Chr3:25465908-25501669 (+)
WSB/EiJ MGP_WSBEiJ_G0026358
 protein coding gene Chr3:25986823-26020145 (+)



Homology
more
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC2A2, solute carrier family 2 member 2
  • Synonyms
    GLUT2
  • Links
    NCBI Gene ID: 6514
    neXtProt AC: NX_P11168
    UniProt: P11168

  • Chr Location
    3q26.2; chr3:170996347-171026743 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc2a2 mouse models; 3 with human SLC2A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are hyperglycemic with hypoinsulinemia and die within 2-3 weeks of life displaying increased plasma levels of glucagon, free fatty acids and beta-hydroxybutyrate, abnormal glucose tolerance, and altered postnatal development of pancreatic islets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    91
  • cDNA Data
    52
  • Literature Summary
    128
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20526 NCBI Gene Model | MGI Sequence Detail 30459 C57BL/6J ±  kb
    transcript NM_031197 RefSeq | MGI Sequence Detail 2571 ZRU/MplStud  
    polypeptide P14246 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000015064 solute carrier family 2, facilitated glucose transporter member 2
      (term hierarchy)
    • InterPro Domains
      IPR045263 Glucose transporter GLUT
      IPR002440 Glucose transporter, type 2 (GLUT2)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      P14246 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 1
      cDNA 52
      Primer pair 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10156, MGD-MRK-10160, MGI:2139657, MGI:95756
    References
    more
    • Summaries
      All 242
      Developmental Gene Expression 128
      Diseases 2
      Gene Ontology 15
      Phenotypes 40
    • Earliest
      J:9978 Asano T, et al., The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein. Nucleic Acids Res. 1989 Aug 11;17(15):6386
    • Latest
      J:352077 Kane E, et al., MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets. iScience. 2024 Jul 19;27(7):110332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory