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Dnm2 Gene Detail
Summary
  • Symbol
    Dnm2
  • Name
    dynamin 2
  • Synonyms
    b2b2159Clo, Dyn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109547
    NCBI Gene: 13430
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21336204-21419055 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1986 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109547
 protein coding gene Chr9:21336167-21419055 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034453
 protein coding gene Chr9:18640540-18726938 (+)
A/J MGP_AJ_G0034431
 protein coding gene Chr9:18316962-18402863 (+)
AKR/J MGP_AKRJ_G0034358
 protein coding gene Chr9:18663831-18757516 (+)
BALB/cJ MGP_BALBcJ_G0034422
 protein coding gene Chr9:18205556-18288964 (+)
C3H/HeJ MGP_C3HHeJ_G0034134
 protein coding gene Chr9:18963618-19048054 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034943
 protein coding gene Chr9:19392552-19484775 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031873
 protein coding gene Chr9:17438708-17521295 (+)
CAST/EiJ MGP_CASTEiJ_G0033457
 protein coding gene Chr9:18788834-18883659 (+)
CBA/J MGP_CBAJ_G0034107
 protein coding gene Chr9:20139304-20232954 (+)
DBA/2J MGP_DBA2J_G0034266
 protein coding gene Chr9:18289078-18373342 (+)
FVB/NJ MGP_FVBNJ_G0034209
 protein coding gene Chr9:17818340-17908357 (+)
LP/J MGP_LPJ_G0034351
 protein coding gene Chr9:18802526-18888434 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034252
 protein coding gene Chr9:21704973-21801273 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034963
 protein coding gene Chr9:18616751-18702312 (+)
PWK/PhJ MGP_PWKPhJ_G0033163
 protein coding gene Chr9:18283648-18369653 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032997
 protein coding gene Chr9:18665264-18756754 (+)
WSB/EiJ MGP_WSBEiJ_G0033572
 protein coding gene Chr9:18335883-18422828 (+)



Homology
more
  • Human Ortholog
    DNM2, dynamin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNM2, dynamin 2
  • Synonyms
    CMT2M, CMTDI1, CMTDIB, DI-CMTB, DYN2, DYNII, LCCS5
  • Links
    NCBI Gene ID: 1785
    neXtProt AC: NX_P50570
    UniProt: P50570

  • Chr Location
    19p13.2; chr19:10718055-10833488 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Dnm2 mouse models; 3 with human DNM2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 9 alleles in 11 genetic backgrounds
    3 phenotypes from multigenic genotypes
    19 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele die prior to E8-E12. Mice heterozygous for a knock-out allele exhibit muscle atrophy and weakness, intermyofibrillar disorganization, and centrally localized mitochondria and sarcoplasmic reticulum.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    129
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    813
  • Tissues
    73
  • cDNA Data
    126
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033335 Ensembl Gene Model | MGI Sequence Detail 82852 C57BL/6J ±  kb
    transcript ENSMUST00000072362 Ensembl | MGI Sequence Detail 3502 Not Applicable  
    polypeptide ENSMUSP00000072199 Ensembl | MGI Sequence Detail 870 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 127
      Primer pair 4

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-39546, MGI:5491163
    References
    more
    • Summaries
      All 133
      Developmental Gene Expression 13
      Diseases 4
      Gene Ontology 15
      Phenotypes 54
    • Earliest
      J:39830 Klocke R, et al., Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively. Genomics. 1997 Apr 15;41(2):290-2
    • Latest
      J:352092 Wang L, et al., Membrane remodeling by FAM92A1 during brain development regulates neuronal morphology, synaptic function, and cognition. Nat Commun. 2024 Jul 23;15(1):6209
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory