Tnnt3 MGI Mouse Gene Detail - MGI:109550 - troponin T3, skeletal, fast

Symbol

Tnnt3
Name

troponin T3, skeletal, fast
Synonyms

fTnT, skeletal muscle fast-twitch TnT

Feature Type

protein coding gene
IDs

MGI:109550
NCBI Gene: 21957
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr7:142052573-142069746 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 87.94 cM
Mapping Data

6 experiments

SNPs within 2kb

269 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109550	protein coding gene	Chr7:142052530-142069746 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033259	protein coding gene	Chr7:147755875-147774610 (+)
A/J	MGP_AJ_G0033242	protein coding gene	Chr7:143491456-143509884 (+)
AKR/J	MGP_AKRJ_G0033174	protein coding gene	Chr7:147519281-147536423 (+)
BALB/cJ	MGP_BALBcJ_G0033243	protein coding gene	Chr7:143263511-143280844 (+)
C3H/HeJ	MGP_C3HHeJ_G0032958	protein coding gene	Chr7:147278687-147295828 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033753	protein coding gene	Chr7:153100347-153117498 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030726	protein coding gene	Chr7:144700440-144717308 (+)
CAST/EiJ	MGP_CASTEiJ_G0032281	protein coding gene	Chr7:139588369-139605286 (+)
CBA/J	MGP_CBAJ_G0032929	protein coding gene	Chr7:158346342-158363517 (+)
DBA/2J	MGP_DBA2J_G0033083	protein coding gene	Chr7:141444409-141461570 (+)
FVB/NJ	MGP_FVBNJ_G0033032	protein coding gene	Chr7:141379486-141396655 (+)
LP/J	MGP_LPJ_G0033176	protein coding gene	Chr7:149266259-149283410 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033066	protein coding gene	Chr7:158965329-158982490 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033772	protein coding gene	Chr7:146467655-146484814 (+)
PWK/PhJ	MGP_PWKPhJ_G0031989	protein coding gene	Chr7:134772097-134789084 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031835	protein coding gene	Chr7:133267005-133283893 (+)
WSB/EiJ	MGP_WSBEiJ_G0032393	protein coding gene	Chr7:147445598-147462856 (+)

Human Ortholog

TNNT3, troponin T3, fast skeletal type

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNNT3, troponin T3, fast skeletal type
Synonyms

beta-TnTF, DA2B2, TNTF
Links

HGNC:11950

NCBI Gene ID: 7140

neXtProt AC: NX_P45378

UniProt: P45378
Chr Location

11p15.5; chr11:1919552-1938706 (+) GRCh38

MGI Vertebrate Homology

Tnnt3 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNNT3
Gene Tree

Tnnt3

Diseases

2 with human TNNT3 associations

				Human Disease	Mouse Models
				distal arthrogryposis type 2B IDs distal arthrogryposis type 2B DOID:0111599 MESH:C538400 ORDO:1147
				distal arthrogryposis type 2B2 IDs distal arthrogryposis type 2B2 DOID:0111601 OMIM:618435

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
4 images
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Radiation induced

1
Targeted

3
Genomic Mutations

1 involving Tnnt3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal lethality, decreased fetal weight, liver and kidney hemorrhage and thin diaphragm. Mice heterozygous for this allele exhibit growth retardation with mild skeleton defects.

less

All GO Annotations

21
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

968
Tissues

96
cDNA Data

97
Literature Summary

36

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tnnt3

ZFIN tnnt3a, tnnt3b

less

All Sequences

191
RefSeq

74
UniProt

21
CCDS

CCDS22031.1, CCDS52451.1, CCDS52452.1, CCDS52453.1, CCDS52454.1, CCDS52455.1, CCDS52456.1, CCDS52457.1, CCDS85471.1, CCDS85472.1, CCDS85473.1, CCDS85474.1, CCDS85475.1, CCDS85476.1, CCDS85477.1

Ensembl

ENSMUSG00000061723 (Evidence)
NCBI Gene

21957

			Length	Strain/Species	Flank
genomic	ENSMUSG00000061723	Ensembl Gene Model \| MGI Sequence Detail	17174	C57BL/6J	± kb
transcript	ENSMUST00000179658	Ensembl \| MGI Sequence Detail	1079	Not Applicable
polypeptide	ENSMUSP00000136278	Ensembl \| MGI Sequence Detail	272	Not Applicable

less

UniProt

21 Sequences
Protein Ontology

PR:000016510 troponin T, fast skeletal muscle

(term hierarchy)
InterPro Domains

IPR001978 Troponin

IPR038077 Troponin domain superfamily

IPR027707 Troponin T

less

All nucleic 116

Genomic 7

cDNA 97

Primer pair 11

Other 1

Microarray probesets 3

less

MGD-MRK-39549

Summaries

All 71

Developmental Gene Expression 36

Gene Ontology 4

Phenotypes 6
Earliest

J:39609 Koch A, et al., cDNA cloning and chromosomal mapping of mouse fast skeletal muscle troponin T. Mamm Genome. 1997 May;8(5):346-8
Latest

J:304923 Doll CF, et al., Gestational intermittent hyperoxia rescues murine genetic congenital heart disease in part. Sci Rep. 2021 Mar 23;11(1):6608

TSS for Tnnt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70191	Chr7:142052569-142052586 (+)	5 bp
Tssr70192	Chr7:142053967-142053981 (+)	1,401 bp
Tssr70193	Chr7:142053997-142054070 (+)	1,461 bp
Tssr70194	Chr7:142055342-142055365 (+)	2,781 bp
Tssr70195	Chr7:142056457-142056465 (+)	3,888 bp
Tssr70196	Chr7:142061457-142061492 (+)	8,902 bp
Tssr70197	Chr7:142063660-142063662 (+)	11,088 bp
Tssr70198	Chr7:142064392-142064412 (+)	11,829 bp
Tssr70199	Chr7:142065008-142065052 (+)	12,457 bp
Tssr70200	Chr7:142065074-142065089 (+)	12,509 bp
Tssr70201	Chr7:142065211-142065238 (+)	12,652 bp
Tssr2457	Chr7:142065252-142065263 (+)	12,685 bp
Tssr70202	Chr7:142065770-142065782 (+)	13,203 bp
Tssr70203	Chr7:142065789-142065807 (+)	13,225 bp
Tssr70204	Chr7:142065984-142065993 (+)	13,416 bp
Tssr70205	Chr7:142066003-142066017 (+)	13,437 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24