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Kif5a Gene Detail
Summary
  • Symbol
    Kif5a
  • Name
    kinesin family member 5A
  • Synonyms
    D10Bwg0738e, Khc, Kif5, Kns
  • Feature Type
    protein coding gene
  • IDs
    MGI:109564
    NCBI Gene: 16572
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127061565-127099217 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1241 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109564
 protein coding gene Chr10:127061564-127102217 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017813
 protein coding gene Chr10:130811877-130850924 (-)
A/J MGP_AJ_G0017788
 protein coding gene Chr10:125571164-125608699 (-)
AKR/J MGP_AKRJ_G0017751
 protein coding gene Chr10:129285613-129323070 (-)
BALB/cJ MGP_BALBcJ_G0017752
 protein coding gene Chr10:125981678-126020154 (-)
C3H/HeJ MGP_C3HHeJ_G0017576
 protein coding gene Chr10:129435895-129475038 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018207
 protein coding gene Chr10:135246820-135287624 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015887
 protein coding gene Chr10:119577215-119616524 (-)
CAST/EiJ MGP_CASTEiJ_G0017136
 protein coding gene Chr10:130090347-130133456 (-)
CBA/J MGP_CBAJ_G0017545
 protein coding gene Chr10:140693562-140738447 (-)
DBA/2J MGP_DBA2J_G0017651
 protein coding gene Chr10:124663690-124701205 (-)
FVB/NJ MGP_FVBNJ_G0017646
 protein coding gene Chr10:123604044-123641552 (-)
LP/J MGP_LPJ_G0017725
 protein coding gene Chr10:131382617-131422496 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017674
 protein coding gene Chr10:143399378-143441834 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018247
 protein coding gene Chr10:129349302-129388637 (-)
PWK/PhJ MGP_PWKPhJ_G0016921
 protein coding gene Chr10:124861668-124903396 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016713
 protein coding gene Chr10:128388787-128425236 (-)
WSB/EiJ MGP_WSBEiJ_G0017197
 protein coding gene Chr10:129578612-129618401 (-)



Homology
more
  • Human Ortholog
    KIF5A, kinesin family member 5A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIF5A, kinesin family member 5A
  • Synonyms
    ALS25, D12S1889, MY050, NEIMY, NKHC, SPG10
  • Links
    NCBI Gene ID: 3798
    neXtProt AC: NX_Q12840
    UniProt: Q12840

  • Chr Location
    12q13.3; chr12:57546026-57586633 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human KIF5A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 5 alleles in 6 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes complete neonatal lethality. Homozygotes delivered by caesarian section are alive at E18.5 but usually die within minutes after birth, exhibiting an abnormal breathing pattern, atelectasis, cyanosis, and abnormal motor neuron morphology in the spinal cord.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1060
  • Tissues
    159
  • cDNA Data
    104
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074657 Ensembl Gene Model | MGI Sequence Detail 37653 C57BL/6J ±  kb
    transcript ENSMUST00000099172 Ensembl | MGI Sequence Detail 6295 Not Applicable  
    polypeptide ENSMUSP00000096775 Ensembl | MGI Sequence Detail 1027 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 106
      Primer pair 3
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-11589, MGD-MRK-34087, MGD-MRK-37432, MGD-MRK-39563, MGI:106394
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 13
      Gene Ontology 19
      Phenotypes 16
    • Earliest
      J:1701 Justice MJ, et al., A molecular genetic linkage map of mouse chromosome 18 reveals extensive linkage conservation with human chromosomes 5 and 18. Genomics. 1992 Aug;13(4):1281-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory