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Tulp1 Gene Detail
Summary
  • Symbol
    Tulp1
  • Name
    TUB like protein 1
  • Synonyms
    Tulp1l
  • Feature Type
    protein coding gene
  • IDs
    MGI:109571
    NCBI Gene: 22157
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:28570489-28584190 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 14.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    34 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109571
 protein coding gene Chr17:28570489-28584196 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023440
 protein coding gene Chr17:27743428-27757079 (-)
A/J MGP_AJ_G0023398
 protein coding gene Chr17:26832928-26847030 (-)
AKR/J MGP_AKRJ_G0023363
 protein coding gene Chr17:27031222-27044735 (-)
BALB/cJ MGP_BALBcJ_G0023403
 protein coding gene Chr17:27100494-27114644 (-)
C3H/HeJ MGP_C3HHeJ_G0023164
 protein coding gene Chr17:27417172-27430822 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023845
 protein coding gene Chr17:28864108-28880763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021320
 protein coding gene Chr17:24205099-24218279 (-)
CAST/EiJ MGP_CASTEiJ_G0022665
 protein coding gene Chr17:27392973-27407682 (-)
CBA/J MGP_CBAJ_G0023138
 protein coding gene Chr17:29897189-29911147 (-)
DBA/2J MGP_DBA2J_G0023269
 protein coding gene Chr17:26387916-26401539 (-)
FVB/NJ MGP_FVBNJ_G0023239
 protein coding gene Chr17:26203030-26216522 (-)
LP/J MGP_LPJ_G0023347
 protein coding gene Chr17:28001552-28017595 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023257
 protein coding gene Chr17:29327116-29340786 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023887
 protein coding gene Chr17:27465315-27481301 (-)
PWK/PhJ MGP_PWKPhJ_G0022415
 protein coding gene Chr17:25197399-25211447 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022233
 protein coding gene Chr17:25459200-25472681 (-)
WSB/EiJ MGP_WSBEiJ_G0022727
 protein coding gene Chr17:27452837-27466342 (-)



Homology
more
  • Human Ortholog
    TULP1, TUB like protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TULP1, TUB like protein 1
  • Synonyms
    LCA15, RP14, TUBL1
  • Links
    NCBI Gene ID: 7287
    neXtProt AC: NX_O00294
    UniProt: O00294

  • Chr Location
    6p21.31; chr6:35497874-35512896 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tulp1 mouse models; 3 with human TULP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    12
  • cDNA Data
    57
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22157 NCBI Gene Model | MGI Sequence Detail 13702 C57BL/6J ±  kb
    transcript NM_021478 RefSeq | MGI Sequence Detail 2085 C57BL/6  
    polypeptide Q9Z273 UniProt | EBI | MGI Sequence Detail 543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 58

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39570
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 18
      Phenotypes 25
    • Earliest
      J:39282 North MA, et al., Molecular characterization of TUB, TULP1, and TULP2, members of the novel tubby gene family and their possible relation to ocular diseases. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3128-33
    • Latest
      J:329579 Palfi A, et al., Non-photoreceptor Expression of Tulp1 May Contribute to Extensive Retinal Degeneration in Tulp1-/- Mice. Front Neurosci. 2020;14:656
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory