Pros1 MGI Mouse Gene Detail - MGI:1095733

Symbol

Pros1
Name

protein S (alpha)
Synonyms

protein S

Feature Type

protein coding gene
IDs

MGI:1095733
NCBI Gene: 19128
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr16:62674670-62749709 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 36.43 cM
Mapping Data

2 experiments

SNPs within 2kb

2432 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1095733	protein coding gene	Chr16:62674670-62749709 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022937	protein coding gene	Chr16:62261271-62342071 (+)
A/J	MGP_AJ_G0022905	protein coding gene	Chr16:59619187-59696359 (+)
AKR/J	MGP_AKRJ_G0022875	protein coding gene	Chr16:61458736-61537745 (+)
BALB/cJ	MGP_BALBcJ_G0022907	protein coding gene	Chr16:59823846-59899630 (+)
C3H/HeJ	MGP_C3HHeJ_G0022669	protein coding gene	Chr16:61775347-61852346 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023355	protein coding gene	Chr16:64130588-64207915 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020858	protein coding gene	Chr16:58783908-58859304 (+)
CAST/EiJ	MGP_CASTEiJ_G0022193	protein coding gene	Chr16:62000181-62075006 (+)
CBA/J	MGP_CBAJ_G0022640	protein coding gene	Chr16:66744808-66833025 (+)
DBA/2J	MGP_DBA2J_G0022772	protein coding gene	Chr16:59386268-59461600 (+)
FVB/NJ	MGP_FVBNJ_G0022746	protein coding gene	Chr16:59032622-59106530 (+)
LP/J	MGP_LPJ_G0022841	protein coding gene	Chr16:62112148-62188582 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022765	protein coding gene	Chr16:67813814-67895434 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023371	protein coding gene	Chr16:61545491-61624751 (+)
PWK/PhJ	MGP_PWKPhJ_G0021935	protein coding gene	Chr16:59572149-59641447 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021765	protein coding gene	Chr16:61297402-61380418 (+)
WSB/EiJ	MGP_WSBEiJ_G0022239	protein coding gene	Chr16:61632455-61708015 (+)

Human Ortholog

PROS1, protein S

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PROS1, protein S
Synonyms

PROS, PS21, PS22, PS23, PS24, PS25, PSA, THPH5, THPH6
Links

HGNC:9456

NCBI Gene ID: 5627

neXtProt AC: NX_P07225

UniProt: P07225
Chr Location

3q11.1; chr3:93873051-93980003 (-) GRCh38

MGI Vertebrate Homology

Pros1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PROS1
Gene Tree

Pros1

Diseases

4 with human PROS1 associations

				Human Disease	Mouse Models
				autosomal dominant thrombophilia due to protein S deficiency IDs autosomal dominant thrombophilia due to protein S deficiency DOID:0111900 OMIM:612336 UMLS_CUI:C3278211
				autosomal recessive thrombophilia due to protein S deficiency IDs autosomal recessive thrombophilia due to protein S deficiency DOID:0111905 OMIM:614514 ORDO:743 UMLS_CUI:C3281092
				cerebral infarction IDs cerebral infarction DOID:3526 ICD10CM:I63 MESH:D002544 NCI:C50486 OMIM:601367 UMLS_CUI:C0007785
				protein S deficiency IDs protein S deficiency DOID:2451 ICD10CM:D68.59 MESH:D018455 NCI:C99026 UMLS_CUI:C0242666

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

29 phenotypes from 3 alleles in 5 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

1
Gene trapped

2
Targeted

8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit neonatal lethality associated with thrombosis, hemorrhage, and thrombocytopenia.

less

All GO Annotations

12
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

755
Tissues

19
cDNA Data

95
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pros1

ZFIN pros1

less

All Sequences

43
RefSeq

4
UniProt

3
CCDS

CCDS28263.1

Ensembl

ENSMUSG00000022912 (Evidence)
NCBI Gene

19128

			Length	Strain/Species	Flank
genomic	19128	NCBI Gene Model \| MGI Sequence Detail	75040	C57BL/6J	± kb
transcript	NM_011173	RefSeq \| MGI Sequence Detail	3314	C57BL/6
polypeptide	Q08761	UniProt \| EBI \| MGI Sequence Detail	675	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000013269 vitamin K-dependent protein S

(term hierarchy)
InterPro Domains

IPR017857 Coagulation factor-like, Gla domain superfamily

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain

IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily

IPR051145 Growth Arrest-Specific/Sex Hormone-Binding/Vitamin K-Dependent

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR001791 Laminin G domain

IPR049883 NOTCH1 EGF-like calcium-binding domain
GlyGen

Q08761 2 sites

less

All nucleic 96

cDNA 95

Primer pair 1

Microarray probesets 3

less

MGI:2146630

Summaries

All 58

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 22
Earliest

J:17594 Chu MD, et al., Cloning and sequencing of a cDNA encoding the murine vitamin K-dependent protein S. Biochim Biophys Acta. 1994 Apr 6;1217(3):325-8
Latest

J:337251 Xia Y, et al., Glutaredoxin 1 regulates cholesterol metabolism and gallstone formation by influencing protein S-glutathionylation. Metabolism. 2023 Jun 3;145:155610

TSS for Pros1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138882	Chr16:62674644-62674651 (+)	-22 bp
Tssr138883	Chr16:62674662-62674673 (+)	-2 bp
Tssr138884	Chr16:62674680-62674696 (+)	18 bp
Tssr138885	Chr16:62674697-62674708 (+)	33 bp
Tssr138886	Chr16:62674710-62674724 (+)	47 bp
Tssr138887	Chr16:62687443-62687470 (+)	12,787 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24