Prpf4b MGI Mouse Gene Detail - MGI:109584 - pre-mRNA processing factor 4B

Symbol

Prpf4b
Name

pre-mRNA processing factor 4B
Synonyms

MGC:5960, Prp4, Prp4k, Prpk

Feature Type

protein coding gene
IDs

MGI:109584
NCBI Gene: 19134
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:35059285-35090047 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 14.21 cM, cytoband A5
Mapping Data

3 experiments

SNPs within 2kb

735 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109584	protein coding gene	Chr13:35058803-35090047 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020453	protein coding gene	Chr13:33016305-33043690 (+)
A/J	MGP_AJ_G0020407	protein coding gene	Chr13:32018131-32045493 (+)
AKR/J	MGP_AKRJ_G0020385	protein coding gene	Chr13:32791393-32819370 (+)
BALB/cJ	MGP_BALBcJ_G0020403	protein coding gene	Chr13:32096025-32123813 (+)
C3H/HeJ	MGP_C3HHeJ_G0020202	protein coding gene	Chr13:32719558-32746854 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020836	protein coding gene	Chr13:34106517-34135479 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018423	protein coding gene	Chr13:30321685-30348975 (+)
CAST/EiJ	MGP_CASTEiJ_G0019717	protein coding gene	Chr13:32392693-32422689 (+)
CBA/J	MGP_CBAJ_G0020163	protein coding gene	Chr13:35579358-35609309 (+)
DBA/2J	MGP_DBA2J_G0020285	protein coding gene	Chr13:31558086-31585535 (+)
FVB/NJ	MGP_FVBNJ_G0020264	protein coding gene	Chr13:31127537-31154906 (+)
LP/J	MGP_LPJ_G0020360	protein coding gene	Chr13:33249782-33277105 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020294	protein coding gene	Chr13:35762374-35789675 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020879	protein coding gene	Chr13:32440542-32467842 (+)
PWK/PhJ	MGP_PWKPhJ_G0019472	protein coding gene	Chr13:31692414-31720577 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019299	protein coding gene	Chr13:31082147-31109773 (+)
WSB/EiJ	MGP_WSBEiJ_G0019779	protein coding gene	Chr13:32809122-32836110 (+)

Human Ortholog

PRP4K, pre-mRNA processing factor kinase PRP4K

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PRP4K, pre-mRNA processing factor kinase PRP4K
Synonyms

dJ1013A10.1, PR4H, PRP4, Prp4B, PRP4H, PRPF4B
Links

HGNC:17346

NCBI Gene ID: 8899

neXtProt AC: NX_Q13523

UniProt: Q13523
Chr Location

6p25.2; chr6:4021267-4064983 (+) GRCh38

MGI Vertebrate Homology

Prpf4b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PRP4K
Gene Tree

Prpf4b

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
1 images
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

9
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Prpf4b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available

Mice homozygous for a knock-out allele show failure of blastocyst formation, failure of blastocyst to hatch from the zona pellucida, increased cell death, and complete embryonic lethality before implantation.

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All GO Annotations

47
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

16
cDNA Data

20
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase prp4k

ZFIN prpf4ba, prpf4bb

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All Sequences

110
RefSeq

44
UniProt

6
CCDS

CCDS26448.1

Ensembl

ENSMUSG00000021413 (Evidence)
NCBI Gene

19134

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021413	Ensembl Gene Model \| MGI Sequence Detail	30763	C57BL/6J	± kb
transcript	ENSMUST00000077853	Ensembl \| MGI Sequence Detail	7844	Not Applicable
polypeptide	ENSMUSP00000077019	Ensembl \| MGI Sequence Detail	1007	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000013286 serine/threonine-protein kinase PRP4

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050494 Serine/threonine and dual-specificity kinase

IPR008271 Serine/threonine-protein kinase, active site

IPR044092 Serine/threonine-protein PRP4, catalytic domain
GlyGen

Q61136 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 9

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MGD-MRK-39583

Summaries

All 55

Developmental Gene Expression 4

Gene Ontology 11

Phenotypes 21
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Prpf4b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119227	Chr13:35059471-35059498 (+)	200 bp
Tssr119228	Chr13:35059503-35059545 (+)	239 bp
Tssr119229	Chr13:35059546-35059585 (+)	281 bp
Tssr119230	Chr13:35059586-35059587 (+)	302 bp
Tssr119231	Chr13:35067208-35067233 (+)	7,936 bp
Tssr119232	Chr13:35067570-35067583 (+)	8,292 bp
Tssr119233	Chr13:35072134-35072147 (+)	12,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24