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Nfic Gene Detail
Summary
  • Symbol
    Nfic
  • Name
    nuclear factor I/C
  • Synonyms
    1110019L22Rik, 1500041O16Rik, NF1-C, nuclear factor 1-C2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109591
    NCBI Gene: 18029
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:81232025-81267753 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109591
 protein coding gene Chr10:81232020-81291469 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017559
 protein coding gene Chr10:82110502-82146957 (-)
A/J MGP_AJ_G0017537
 protein coding gene Chr10:79200765-79236603 (-)
AKR/J MGP_AKRJ_G0017498
 protein coding gene Chr10:81376130-81410918 (-)
BALB/cJ MGP_BALBcJ_G0017499
 protein coding gene Chr10:79420342-79458023 (-)
C3H/HeJ MGP_C3HHeJ_G0017322
 protein coding gene Chr10:81477458-81513291 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017953
 protein coding gene Chr10:84929234-84967973 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015642
 protein coding gene Chr10:75399039-75434051 (-)
CAST/EiJ MGP_CASTEiJ_G0016889
 protein coding gene Chr10:81707397-81751821 (-)
CBA/J MGP_CBAJ_G0017294
 protein coding gene Chr10:88243852-88295547 (-)
DBA/2J MGP_DBA2J_G0017400
 protein coding gene Chr10:78404561-78439554 (-)
FVB/NJ MGP_FVBNJ_G0017394
 protein coding gene Chr10:77656816-77694841 (-)
LP/J MGP_LPJ_G0017471
 protein coding gene Chr10:82557397-82596848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017420
 protein coding gene Chr10:90085327-90136271 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017994
 protein coding gene Chr10:81386244-81421021 (-)
PWK/PhJ MGP_PWKPhJ_G0016670
 protein coding gene Chr10:78299267-78331328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016460
 protein coding gene Chr10:80335183-80371772 (-)
WSB/EiJ MGP_WSBEiJ_G0016949
 protein coding gene Chr10:81419038-81459982 (-)



Homology
more
  • Human Ortholog
    NFIC, nuclear factor I C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NFIC, nuclear factor I C
  • Synonyms
    CTF, CTF5, NF-I, NFI
  • Links
    NCBI Gene ID: 4782
    neXtProt AC: NX_P08651
    UniProt: P08651

  • Chr Location
    19p13.3; chr19:3314403-3469217 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele have abnormal incisor and molar root development, show reduced alveolar bone formation, and exhibit impaired feeding leading to severe runting and premature death when reared on standard laboratory chow.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    892
  • Tissues
    101
  • cDNA Data
    22
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18029 NCBI Gene Model | MGI Sequence Detail 35729 C57BL/6J ±  kb
    transcript NM_008688 RefSeq | MGI Sequence Detail 6295 ZRU/MplStud  
    polypeptide P70255 UniProt | EBI | MGI Sequence Detail 439 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000011175 nuclear factor 1 C-type
      (term hierarchy)
    • InterPro Domains
      IPR000647 CTF transcription factor/nuclear factor 1
      IPR019739 CTF transcription factor/nuclear factor 1, conserved site
      IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
      IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
      IPR003619 MAD homology 1, Dwarfin-type
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-39590, MGI:1915780, MGI:1916250, MGI:2143494, MGI:2143666
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 15
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:337474 Cobo I, et al., NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat Commun. 2023 Jun 23;14(1):3761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory