About   Help   FAQ
Neurog2 Gene Detail
Summary
  • Symbol
    Neurog2
  • Name
    neurogenin 2
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109619
    NCBI Gene: 11924
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:127426784-127429280 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109619
 protein coding gene Chr3:127426382-127429285 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027863
 protein coding gene Chr3:130137877-130140372 (+)
A/J MGP_AJ_G0027821
 protein coding gene Chr3:125683067-125685562 (+)
AKR/J MGP_AKRJ_G0027786
 protein coding gene Chr3:128929803-128932299 (+)
BALB/cJ MGP_BALBcJ_G0027834
 protein coding gene Chr3:125542901-125545396 (+)
C3H/HeJ MGP_C3HHeJ_G0027563
 protein coding gene Chr3:129312739-129315234 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028278
 protein coding gene Chr3:134832681-134835177 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025616
 protein coding gene Chr3:120929275-120931770 (+)
CAST/EiJ MGP_CASTEiJ_G0027020
 protein coding gene Chr3:128867266-128904976 (+)
CBA/J MGP_CBAJ_G0027539
 protein coding gene Chr3:139392889-139395384 (+)
DBA/2J MGP_DBA2J_G0027680
 protein coding gene Chr3:124898763-124901266 (+)
FVB/NJ MGP_FVBNJ_G0027647
 protein coding gene Chr3:122464570-122467066 (+)
LP/J MGP_LPJ_G0027789
 protein coding gene Chr3:131684150-131686645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027678
 protein coding gene Chr3:147311224-147313726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028335
 protein coding gene Chr3:128562818-128565314 (+)
PWK/PhJ MGP_PWKPhJ_G0026744
 protein coding gene Chr3:124631366-124661892 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026569
 protein coding gene Chr3:126648744-126681731 (+)
WSB/EiJ MGP_WSBEiJ_G0027099
 protein coding gene Chr3:129288961-129292089 (+)



Homology
more
  • Human Ortholog
    NEUROG2, neurogenin 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROG2, neurogenin 2
  • Synonyms
    Atoh4, bHLHa8, Math4A, ngn-2, NGN2
  • Links
    NCBI Gene ID: 63973
    neXtProt AC: NX_Q9H2A3
    UniProt: Q9H2A3

  • Chr Location
    4q25; chr4:112513516-112516180 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 6 alleles in 5 genetic backgrounds
    28 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die after birth and have neuronal differentiation defects, affecting retinal development, spinal cord interneuron development and behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1698
  • Tissues
    345
  • cDNA Data
    29
  • Literature Summary
    465
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027967 Ensembl Gene Model | MGI Sequence Detail 2497 C57BL/6J ±  kb
    transcript ENSMUST00000029587 Ensembl | MGI Sequence Detail 2227 Not Applicable  
    polypeptide ENSMUSP00000029587 Ensembl | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 2
      cDNA 36
      Primer pair 10
      Other 40

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39618
    References
    more
    • Summaries
      All 540
      Developmental Gene Expression 465
      Diseases 1
      Gene Ontology 17
      Phenotypes 100
    • Earliest
      J:37090 Gradwohl G, et al., Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors. Dev Biol. 1996 Nov 25;180(1):227-41
    • Latest
      J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory