Lst1 MGI Mouse Gene Detail - MGI:1096324 - leukocyte specific transcript 1

Symbol

Lst1
Name

leukocyte specific transcript 1
Synonyms

B144

Feature Type

protein coding gene
IDs

MGI:1096324
NCBI Gene: 16988
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr17:35404071-35407415 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.59 cM
Mapping Data

1 experiment

Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096324	protein coding gene	Chr17:35404071-35407416 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023626	protein coding gene	Chr17:35332820-35336009 (-)
A/J	no annotation
AKR/J	MGP_AKRJ_G0023554	protein coding gene	Chr17:34636063-34639407 (-)
BALB/cJ	MGP_BALBcJ_G0023592	protein coding gene	Chr17:34298248-34301701 (-)
C3H/HeJ	MGP_C3HHeJ_G0023353	protein coding gene	Chr17:35040254-35043562 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0024031	protein coding gene	Chr17:36677690-36681601 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021512	protein coding gene	Chr17:31929088-31932499 (-)
CAST/EiJ	MGP_CASTEiJ_G0022849	protein coding gene	Chr17:35039142-35042518 (-)
CBA/J	MGP_CBAJ_G0023331	protein coding gene	Chr17:38189501-38192783 (-)
DBA/2J	MGP_DBA2J_G0023459	protein coding gene	Chr17:33481915-33486463 (-)
FVB/NJ	MGP_FVBNJ_G0023426	protein coding gene	Chr17:33324752-33328169 (-)
LP/J	MGP_LPJ_G0023536	protein coding gene	Chr17:35663252-35666573 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023448	protein coding gene	Chr17:37116077-37120438 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024076	protein coding gene	Chr17:34863379-34868021 (-)
PWK/PhJ	MGP_PWKPhJ_G0022597	protein coding gene	Chr17:32319087-32322453 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022417	protein coding gene	Chr17:32871096-32874421 (-)
WSB/EiJ	MGP_WSBEiJ_G0022913	protein coding gene	Chr17:34987141-34990311 (-)

Human Ortholog

LST1, leukocyte specific transcript 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LST1, leukocyte specific transcript 1
Synonyms

B144, D6S49E, LST-1
Links

HGNC:14189

NCBI Gene ID: 7940

neXtProt AC: NX_O00453

UniProt: O00453
Chr Location

6p21.33; chr6:31586124-31588909 (+) GRCh38

MGI Vertebrate Homology

Lst1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LST1
Protein SuperFamily

Leukocyte-sp_tscrpt_1_LST1
Gene Tree

Lst1

Diseases

1 with human LST1 associations

				Human Disease	Mouse Models
				graft-versus-host disease IDs graft-versus-host disease DOID:0081267 MESH:D006086 OMIM:614395 ORDO:39812

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

1
Gene trapped

7
Targeted

2
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele are slightly more susceptible to influenza A H1N1 infection.

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All GO Annotations

15
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

5
cDNA Data

19
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

2
UniProt

7
CCDS

CCDS50085.1

Ensembl

ENSMUSG00000073412 (Evidence)
NCBI Gene

16988

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073412	Ensembl Gene Model \| MGI Sequence Detail	3345	C57BL/6J	± kb
transcript	ENSMUST00000097336	Ensembl \| MGI Sequence Detail	415	Not Applicable
polypeptide	ENSMUSP00000094949	Ensembl \| MGI Sequence Detail	93	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000009970 leukocyte-specific transcript 1 protein

(term hierarchy)
InterPro Domains

IPR007775 Leukocyte-specific transcript 1, LST-1

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All nucleic 22

Genomic 2

cDNA 19

Primer pair 1

Microarray probesets 3

Summaries

All 40

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 11
Earliest

J:8883 Tsuge I, et al., A gene in the H-2S:H-2D interval of the major histocompatibility complex which is transcribed in B cells and macrophages. Immunogenetics. 1987;26(6):378-80
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lst1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147791	Chr17:35409210-35409234 (-)	-1,807 bp
Tssr147790	Chr17:35407403-35407422 (-)	2 bp
Tssr147789	Chr17:35405941-35405982 (-)	1,453 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24