Axin1 MGI Mouse Gene Detail - MGI:1096327

Symbol

Axin1
Name

axin 1

Feature Type

protein coding gene
IDs

MGI:1096327
NCBI Gene: 12005
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:26357662-26414785 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 13.07 cM
Mapping Data

15 experiments

SNPs within 2kb

1124 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096327	protein coding gene	Chr17:26350294-26414785 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023392	protein coding gene	Chr17:25275583-25342983 (+)
A/J	MGP_AJ_G0023351	protein coding gene	Chr17:24529234-24587023 (+)
AKR/J	MGP_AKRJ_G0023317	protein coding gene	Chr17:24637771-24698072 (+)
BALB/cJ	MGP_BALBcJ_G0023356	protein coding gene	Chr17:24749090-24808297 (+)
C3H/HeJ	MGP_C3HHeJ_G0023116	protein coding gene	Chr17:25028809-25090311 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023798	protein coding gene	Chr17:26344722-26406631 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021274	protein coding gene	Chr17:21986036-22046012 (+)
CAST/EiJ	MGP_CASTEiJ_G0022618	protein coding gene	Chr17:24930895-24998081 (+)
CBA/J	MGP_CBAJ_G0023091	protein coding gene	Chr17:27275084-27342697 (+)
DBA/2J	MGP_DBA2J_G0023221	protein coding gene	Chr17:24123145-24180349 (+)
FVB/NJ	MGP_FVBNJ_G0023191	protein coding gene	Chr17:23884199-23942822 (+)
LP/J	MGP_LPJ_G0023298	protein coding gene	Chr17:25561415-25621640 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023210	protein coding gene	Chr17:26845670-26912735 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023838	protein coding gene	Chr17:24985941-25048492 (+)
PWK/PhJ	MGP_PWKPhJ_G0022367	protein coding gene	Chr17:22891208-22950783 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022185	protein coding gene	Chr17:23050832-23115322 (+)
WSB/EiJ	MGP_WSBEiJ_G0022681	protein coding gene	Chr17:25010305-25069908 (+)

Human Ortholog

AXIN1, axin 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

AXIN1, axin 1
Synonyms

AXIN, CMDOH, PPP1R49
Links

HGNC:903

NCBI Gene ID: 8312

neXtProt AC: NX_O15169

UniProt: O15169
Chr Location

16p13.3; chr16:287440-352723 (-) GRCh38

MGI Vertebrate Homology

Axin1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: AXIN1
Gene Tree

Axin1

Diseases

3 with human AXIN1 associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

62 phenotypes from 7 alleles in 15 genetic backgrounds
20 phenotypes from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

3
Gene trapped

7
Radiation induced

2
Spontaneous

3
Targeted

14
Transgenic

1
Genomic Mutations

2 involving Axin1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutant homozygotes die at embryonic day 8-10, exhibiting neuroectodermal defects and axial duplications. Heterozygotes exhibit skeletal, cardiac, and neurological defects including short, bent tails, and deafness with circling behavior.

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All GO Annotations

167
GO References

52

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

892
Tissues

119
cDNA Data

110
Literature Summary

29

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA AXIN1

Xenbase axin1

ZFIN axin1

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All Sequences

58
RefSeq

12
UniProt

6
CCDS

CCDS28547.2, CCDS50042.1

Ensembl

ENSMUSG00000024182 (Evidence)
NCBI Gene

12005

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024182	Ensembl Gene Model \| MGI Sequence Detail	57124	C57BL/6J	± kb
transcript	ENSMUST00000074370	Ensembl \| MGI Sequence Detail	3777	Not Applicable
polypeptide	ENSMUSP00000073974	Ensembl \| MGI Sequence Detail	863	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004526 Axin-1

(term hierarchy)
PDB

3UTM, 8VME, 8VMF
InterPro Domains

IPR032101 Axin-1/2, tankyrase-binding domain

IPR014936 Axin beta-catenin binding

IPR043581 Axin-like

IPR001158 DIX domain

IPR038207 DIX domain superfamily

IPR016137 RGS domain

IPR036305 RGS domain superfamily

IPR024066 RGS, subdomain 1/3

IPR044926 RGS, subdomain 2

IPR029071 Ubiquitin-like domain superfamily

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All nucleic 123

cDNA 113

Primer pair 9

Other 1

Microarray probesets 4

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MGD-MRK-11553, MGD-MRK-11586, MGD-MRK-9891, MGI:2146821, MGI:95592

Summaries

All 173

Developmental Gene Expression 29

Gene Ontology 52

Phenotypes 50
Earliest

J:12953 Reed SC, The Inheritance and Expression of Fused, a New Mutation in the House Mouse. Genetics. 1937 Jan;22(1):1-13
Latest

J:358517 Li M, et al., AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res. 2024 Oct;34(10):683-706

TSS for Axin1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr143213	Chr17:26357635-26357743 (+)	27 bp
Tssr143214	Chr17:26378646-26378648 (+)	20,985 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24