Slc1a6 MGI Mouse Gene Detail - MGI:1096331 - solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

Symbol

Slc1a6
Name

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6
Synonyms

EAAT4

Feature Type

protein coding gene
IDs

MGI:1096331
NCBI Gene: 20513
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:78616330-78650599 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

SNPs within 2kb

759 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096331	protein coding gene	Chr10:78615923-78650659 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017430	protein coding gene	Chr10:79245928-79274874 (+)
A/J	MGP_AJ_G0017408	protein coding gene	Chr10:76496386-76524310 (+)
AKR/J	MGP_AKRJ_G0017371	protein coding gene	Chr10:78540344-78567857 (+)
BALB/cJ	MGP_BALBcJ_G0017370	protein coding gene	Chr10:76653597-76687141 (+)
C3H/HeJ	MGP_C3HHeJ_G0017193	protein coding gene	Chr10:78648835-78676744 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017826	protein coding gene	Chr10:82035562-82065463 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015517	protein coding gene	Chr10:72793992-72848078 (+)
CAST/EiJ	MGP_CASTEiJ_G0016763	protein coding gene	Chr10:78948361-78977997 (+)
CBA/J	MGP_CBAJ_G0017165	protein coding gene	Chr10:85169815-85203662 (+)
DBA/2J	MGP_DBA2J_G0017273	protein coding gene	Chr10:75720158-75748103 (+)
FVB/NJ	MGP_FVBNJ_G0017265	protein coding gene	Chr10:74898880-74933088 (+)
LP/J	MGP_LPJ_G0017344	protein coding gene	Chr10:79701328-79729784 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017292	protein coding gene	Chr10:87141357-87168832 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017868	protein coding gene	Chr10:78583637-78622016 (+)
PWK/PhJ	MGP_PWKPhJ_G0016545	protein coding gene	Chr10:75610546-75640872 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016330	protein coding gene	Chr10:77783499-77817649 (+)
WSB/EiJ	MGP_WSBEiJ_G0016823	protein coding gene	Chr10:78572363-78601852 (+)

Human Ortholog

SLC1A6, solute carrier family 1 member 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC1A6, solute carrier family 1 member 6
Synonyms

EAAT4
Links

HGNC:10944

NCBI Gene ID: 6511

neXtProt AC: NX_P48664

UniProt: P48664
Chr Location

19p13.12; chr19:14950033-15022990 (-) GRCh38

MGI Vertebrate Homology

Slc1a6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC1A6
Gene Tree

Slc1a6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Slc1a6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available

Mice homozygous for disruptions in this gene survive well and display no obvious abnormalities of behavior or brain structure.

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All GO Annotations

41
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

768
Tissues

36
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc1a6

ZFIN slc1a6

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All Sequences

44
RefSeq

10
UniProt

4
CCDS

CCDS23970.1

Ensembl

ENSMUSG00000005357 (Evidence)
NCBI Gene

20513

			Length	Strain/Species	Flank
genomic	ENSMUSG00000005357	Ensembl Gene Model \| MGI Sequence Detail	34270	C57BL/6J	± kb
transcript	ENSMUST00000005490	Ensembl \| MGI Sequence Detail	2029	Not Applicable
polypeptide	ENSMUSP00000005490	Ensembl \| MGI Sequence Detail	561	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000014977 excitatory amino acid transporter 4

(term hierarchy)
InterPro Domains

IPR050746 Dicarboxylate/Amino Acid:Cation Symporter

IPR001991 Sodium:dicarboxylate symporter

IPR018107 Sodium:dicarboxylate symporter, conserved site

IPR036458 Sodium:dicarboxylate symporter superfamily
GlyGen

O35544 3 sites

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All nucleic 21

Genomic 10

cDNA 8

Primer pair 1

Other 2

Microarray probesets 3

Summaries

All 57

Developmental Gene Expression 8

Gene Ontology 9

Phenotypes 16
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Slc1a6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94349	Chr10:78616182-78616226 (+)	-126 bp
Tssr94350	Chr10:78616304-78616375 (+)	10 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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