E2f2 MGI Mouse Gene Detail - MGI:1096341 - E2F transcription factor 2

Symbol

E2f2
Name

E2F transcription factor 2

Feature Type

protein coding gene
IDs

MGI:1096341
NCBI Gene: 242705
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr4:135899705-135923368 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 68.34 cM, cytoband D3
Mapping Data

2 experiments

SNPs within 2kb

812 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1096341	protein coding gene	Chr4:135899585-135923368 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028961	protein coding gene	Chr4:138700135-138723856 (+)
A/J	MGP_AJ_G0028920	protein coding gene	Chr4:132805126-132828786 (+)
AKR/J	MGP_AKRJ_G0028872	protein coding gene	Chr4:136646001-136669664 (+)
BALB/cJ	MGP_BALBcJ_G0028944	protein coding gene	Chr4:133467450-133491149 (+)
C3H/HeJ	MGP_C3HHeJ_G0028658	protein coding gene	Chr4:136921863-136945522 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029385	protein coding gene	Chr4:143622593-143646190 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026656	protein coding gene	Chr4:125839645-125864253 (+)
CAST/EiJ	MGP_CASTEiJ_G0028090	protein coding gene	Chr4:135061532-135086720 (+)
CBA/J	MGP_CBAJ_G0028623	protein coding gene	Chr4:147553922-147579665 (+)
DBA/2J	MGP_DBA2J_G0028772	protein coding gene	Chr4:133222794-133246674 (+)
FVB/NJ	MGP_FVBNJ_G0028739	protein coding gene	Chr4:132163576-132189709 (+)
LP/J	MGP_LPJ_G0028871	protein coding gene	Chr4:138789717-138813487 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028765	protein coding gene	Chr4:151801166-151824994 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029423	protein coding gene	Chr4:137100638-137124313 (+)
PWK/PhJ	MGP_PWKPhJ_G0027810	protein coding gene	Chr4:129996587-130020429 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027636	protein coding gene	Chr4:132919209-132944623 (+)
WSB/EiJ	MGP_WSBEiJ_G0028168	protein coding gene	Chr4:137271493-137295146 (+)

Human Ortholog

E2F2, E2F transcription factor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

E2F2, E2F transcription factor 2
Synonyms

E2F-2
Links

HGNC:3114

NCBI Gene ID: 1870

neXtProt AC: NX_Q14209

UniProt: Q14209
Chr Location

1p36.12; chr1:23505212-23531233 (-) GRCh38

MGI Vertebrate Homology

E2f2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: E2F2
Gene Tree

E2f2

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Phenotype Summary

24 phenotypes from 1 allele in 1 genetic background
18 phenotypes from multigenic genotypes
53 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

10
Targeted

2
Genomic Mutations

3 involving E2f2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit premature death with signs of inflammatory and autoimmune disorders such as increased memory T cells, enlarged spleen, glomerulonephritis, inflammed liver, inflammed lung, increased double stranded DNA antibodies, hair loss, and erythema.

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All GO Annotations

29
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

992
Tissues

253
cDNA Data

44
Literature Summary

26

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

49
RefSeq

6
UniProt

4
CCDS

CCDS18801.1

Ensembl

ENSMUSG00000018983 (Evidence)
NCBI Gene

242705

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018983	Ensembl Gene Model \| MGI Sequence Detail	23664	C57BL/6J	± kb
transcript	ENSMUST00000061721	Ensembl \| MGI Sequence Detail	4739	Not Applicable
polypeptide	ENSMUSP00000050047	Ensembl \| MGI Sequence Detail	443	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000006853 transcription factor E2F2

(term hierarchy)
InterPro Domains

IPR003316 E2F/DP family, winged-helix DNA-binding domain

IPR037241 E2F-DP heterodimerization region

IPR015633 E2F Family

IPR032198 E2F transcription factor, CC-MB domain

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily

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All nucleic 50

cDNA 44

Primer pair 5

Other 1

Microarray probesets 4

Summaries

All 127

Developmental Gene Expression 26

Gene Ontology 8

Phenotypes 53
Earliest

J:125251 Karlseder J, et al., Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F. Mol Cell Biol. 1996 Apr;16(4):1659-67
Latest

J:353480 Huang S, et al., Mutations in linker-2 of KLF1 impair expression of membrane transporters and cytoskeletal proteins causing hemolysis. Nat Commun. 2024 Aug 15;15(1):7019

TSS for E2f2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39670	Chr4:135899577-135899599 (+)	-117 bp
Tssr39671	Chr4:135899678-135899706 (+)	-13 bp
Tssr39672	Chr4:135899707-135899738 (+)	18 bp
Tssr39673	Chr4:135899739-135899753 (+)	41 bp
Tssr39674	Chr4:135899869-135899890 (+)	175 bp
Tssr39675	Chr4:135899977-135900064 (+)	316 bp
Tssr39676	Chr4:135900161-135900171 (+)	461 bp
Tssr39677	Chr4:135900256-135900267 (+)	557 bp
Tssr39678	Chr4:135900478-135900489 (+)	779 bp
Tssr39679	Chr4:135905247-135905268 (+)	5,553 bp
Tssr39680	Chr4:135905523-135905546 (+)	5,830 bp
Tssr39681	Chr4:135905551-135905564 (+)	5,853 bp
Tssr39682	Chr4:135905584-135905597 (+)	5,886 bp
Tssr39683	Chr4:135907509-135907522 (+)	7,811 bp
Tssr39684	Chr4:135908086-135908101 (+)	8,389 bp
Tssr39685	Chr4:135908103-135908120 (+)	8,407 bp
Tssr39686	Chr4:135908454-135908475 (+)	8,760 bp
Tssr39687	Chr4:135916810-135916813 (+)	17,107 bp
Tssr39688	Chr4:135920219-135920231 (+)	20,520 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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