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Rhoa Gene Detail
Summary
  • Symbol
    Rhoa
  • Name
    ras homolog family member A
  • Synonyms
    Arha, Arha1, Arha2, RhoA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096342
    NCBI Gene: 11848
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:108183359-108215142 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 59.20 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    763 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096342
 protein coding gene Chr9:108183328-108215142 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035292
 protein coding gene Chr9:110251490-110286979 (+)
A/J MGP_AJ_G0035271
 protein coding gene Chr9:106215067-106246377 (+)
AKR/J MGP_AKRJ_G0035203
 protein coding gene Chr9:108865367-108895648 (+)
BALB/cJ MGP_BALBcJ_G0035265
 protein coding gene Chr9:105912949-105943203 (+)
C3H/HeJ MGP_C3HHeJ_G0034975
 protein coding gene Chr9:109261968-109293696 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035785
 protein coding gene Chr9:113239585-113280248 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032683
 protein coding gene Chr9:103647595-103671427 (+)
CAST/EiJ MGP_CASTEiJ_G0034286
 protein coding gene Chr9:109234509-109264821 (+)
CBA/J MGP_CBAJ_G0034943
 protein coding gene Chr9:117247502-117271667 (+)
DBA/2J MGP_DBA2J_G0035104
 protein coding gene Chr9:105672596-105703067 (+)
FVB/NJ MGP_FVBNJ_G0035052
 protein coding gene Chr9:104437814-104468042 (+)
LP/J MGP_LPJ_G0035180
 protein coding gene Chr9:110451313-110485254 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035091
 protein coding gene Chr9:118833951-118866043 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035806
 protein coding gene Chr9:109161199-109191785 (+)
PWK/PhJ MGP_PWKPhJ_G0033993
 protein coding gene Chr9:105999483-106028948 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033829
 protein coding gene Chr9:109219024-109243985 (+)
WSB/EiJ MGP_WSBEiJ_G0034407
 protein coding gene Chr9:109033940-109064300 (+)



Homology
more
  • Human Ortholog
    RHOA, ras homolog family member A
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOA, ras homolog family member A
  • Synonyms
    ARH12, ARHA, EDFAOB, RHO12, RHOH12
  • Links
    NCBI Gene ID: 387
    neXtProt AC: NX_P61586
    UniProt: P61586

  • Chr Location
    3p21.31; chr3:49359139-49412998 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RHOA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 4 alleles in 5 genetic backgrounds
    11 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neuroepithelial cells exhibit lethality during late embryonic stages associated with early cell cycle exit, premature neuronal precursor differentiation, increased apoptosis in the neural tube.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    192
  • GO References
    50
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    145
  • cDNA Data
    14
  • Literature Summary
    78
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11848 NCBI Gene Model | MGI Sequence Detail 31784 C57BL/6J ±  kb
    transcript NM_016802 RefSeq | MGI Sequence Detail 2191 C57BL/6  
    polypeptide Q9QUI0 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 14
      Primer pair 7
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1355308
    References
    more
    • Summaries
      All 371
      Developmental Gene Expression 78
      Gene Ontology 50
      Phenotypes 73
    • Earliest
      J:87888 Ridley AJ, et al., The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell. 1992 Aug 7;70(3):389-99
    • Latest
      J:353553 Despin-Guitard E, et al., Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory