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Lhx8 Gene Detail
Summary
  • Symbol
    Lhx8
  • Name
    LIM homeobox protein 8
  • Synonyms
    L3, Lhx7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096343
    NCBI Gene: 16875
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:154011925-154036190 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 79.12 cM, cytoband H3-H4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    634 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096343
 protein coding gene Chr3:154011925-154036296 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028002
 protein coding gene Chr3:158319679-158345226 (-)
A/J MGP_AJ_G0027961
 protein coding gene Chr3:152532075-152556724 (-)
AKR/J MGP_AKRJ_G0027927
 protein coding gene Chr3:156617255-156641628 (-)
BALB/cJ MGP_BALBcJ_G0027973
 protein coding gene Chr3:152343242-152367362 (-)
C3H/HeJ MGP_C3HHeJ_G0027703
 protein coding gene Chr3:156984851-157014885 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028416
 protein coding gene Chr3:163480909-163508128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025754
 protein coding gene Chr3:147300378-147324217 (-)
CAST/EiJ MGP_CASTEiJ_G0027156
 protein coding gene Chr3:157112279-157137780 (-)
CBA/J MGP_CBAJ_G0027678
 protein coding gene Chr3:169368180-169392416 (-)
DBA/2J MGP_DBA2J_G0027818
 protein coding gene Chr3:151605924-151630230 (-)
FVB/NJ MGP_FVBNJ_G0027785
 protein coding gene Chr3:148983080-149007404 (-)
LP/J MGP_LPJ_G0027929
 protein coding gene Chr3:159630528-159659309 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027818
 protein coding gene Chr3:177807980-177835540 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028475
 protein coding gene Chr3:156256175-156282509 (-)
PWK/PhJ MGP_PWKPhJ_G0026879
 protein coding gene Chr3:151529635-151553798 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026707
 protein coding gene Chr3:154418975-154444067 (-)
WSB/EiJ MGP_WSBEiJ_G0027236
 protein coding gene Chr3:157234159-157258321 (-)



Homology
more
  • Human Ortholog
    LHX8, LIM homeobox 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHX8, LIM homeobox 8
  • Synonyms
    LHX7
  • Links
    NCBI Gene ID: 431707
    neXtProt AC: NX_Q68G74
    UniProt: Q68G74

  • Chr Location
    1p31.1; chr1:75128434-75199454 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 4 alleles in 6 genetic backgrounds
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice exhibit a cleft palate with partial penetrance and die neonatally; those without cleft palate survive to adulthood. All mice show defective cholinergic neuron development. Females show autophagy of oocytes associated with DNA damage, ovary fibrosis, and premature ovarian failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1077
  • Tissues
    294
  • cDNA Data
    28
  • Literature Summary
    109
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16875 NCBI Gene Model | MGI Sequence Detail 24266 C57BL/6J ±  kb
    transcript NM_010713 RefSeq | MGI Sequence Detail 1971 C57BL/6  
    polypeptide O35652 UniProt | EBI | MGI Sequence Detail 367 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 5
      cDNA 30
      Primer pair 9
      Other 12

      Microarray probesets 3
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 109
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:31813 Matsumoto K, et al., L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Neurosci Lett. 1996 Feb 2;204(1-2):113-6
    • Latest
      J:339096 Biswas S, et al., The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus. Dev Biol. 2023 Aug 1;503:10-24
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory