About   Help   FAQ
Gp5 Gene Detail
Summary
  • Symbol
    Gp5
  • Name
    glycoprotein 5 platelet
  • Synonyms
    GP V, GPV
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096363
    NCBI Gene: 14729
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:30126503-30129597 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 21.26 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096363
 protein coding gene Chr16:30126503-30129599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022711
 protein coding gene Chr16:28197153-28200247 (-)
A/J MGP_AJ_G0022674
 protein coding gene Chr16:26901828-26904922 (-)
AKR/J MGP_AKRJ_G0022648
 protein coding gene Chr16:27918125-27921219 (-)
BALB/cJ MGP_BALBcJ_G0022678
 protein coding gene Chr16:27079816-27082910 (-)
C3H/HeJ MGP_C3HHeJ_G0022443
 protein coding gene Chr16:28025670-28028763 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023127
 protein coding gene Chr16:28805621-28808714 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020645
 protein coding gene Chr16:27338887-27341972 (-)
CAST/EiJ MGP_CASTEiJ_G0021971
 protein coding gene Chr16:28111578-28114683 (-)
CBA/J MGP_CBAJ_G0022413
 protein coding gene Chr16:30018282-30021375 (-)
DBA/2J MGP_DBA2J_G0022546
 protein coding gene Chr16:26781744-26784837 (-)
FVB/NJ MGP_FVBNJ_G0022521
 protein coding gene Chr16:26753683-26756777 (-)
LP/J MGP_LPJ_G0022613
 protein coding gene Chr16:28012520-28015613 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022540
 protein coding gene Chr16:29546340-29549434 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023139
 protein coding gene Chr16:27881387-27884481 (-)
PWK/PhJ MGP_PWKPhJ_G0021710
 protein coding gene Chr16:27079860-27082962 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021541
 protein coding gene Chr16:27645284-27648384 (-)
WSB/EiJ MGP_WSBEiJ_G0022015
 protein coding gene Chr16:27831417-27834510 (-)



Homology
more
  • Human Ortholog
    GP5, glycoprotein V platelet
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GP5, glycoprotein V platelet
  • Synonyms
    CD42d, GPV
  • Links
    NCBI Gene ID: 2814
    neXtProt AC: NX_P40197
    UniProt: P40197

  • Chr Location
    3q29; chr3:194394821-194399266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for one null allele develop normally with no spontaneous bleeding while their platelets show normal thrombin responsiveness and lack a Bernard-Soulier phenotype. In contrast, homozygotes for a second null allele show a shorter bleeding time and platelet hyperresponsiveness to thrombin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    721
  • Tissues
    9
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047953 Ensembl Gene Model | MGI Sequence Detail 3095 C57BL/6J ±  kb
transcript ENSMUST00000061190 Ensembl | MGI Sequence Detail 2197 Not Applicable  
polypeptide ENSMUSP00000051895 Ensembl | MGI Sequence Detail 567 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001909 platelet glycoprotein V
    (term hierarchy)
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR050467 Leucine-rich repeat and fibronectin type-III domain-containing
    IPR032675 Leucine-rich repeat domain superfamily
    IPR003591 Leucine-rich repeat, typical subtype
  • GlyGen
    O08742 7 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 5
    Genomic 2
    cDNA 3

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 5
  • Earliest
    J:40027 Ravanat C, et al., Gene cloning of rat and mouse platelet glycoprotein V: identification of megakaryocyte-specific promoters and demonstration of functional thrombin cleavage. Blood. 1997 May 1;89(9):3253-62
  • Latest
    J:225923 Potts KS, et al., Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL. Blood. 2015 Aug 6;126(6):807-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory