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Cyp4a14 Gene Detail
Summary
  • Symbol
    Cyp4a14
  • Name
    cytochrome P450, family 4, subfamily a, polypeptide 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096550
    NCBI Gene: 13119
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115343397-115353339 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096550
 protein coding gene Chr4:115343397-115353355 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028601
 protein coding gene Chr4:116293791-116304456 (-)
A/J MGP_AJ_G0028561
 protein coding gene Chr4:111854390-111864324 (-)
AKR/J MGP_AKRJ_G0028511
 protein coding gene Chr4:114187928-114197860 (-)
BALB/cJ MGP_BALBcJ_G0028583
 protein coding gene Chr4:112470585-112480533 (-)
C3H/HeJ MGP_C3HHeJ_G0028297
 protein coding gene Chr4:115783536-115793468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029024
 protein coding gene Chr4:120796272-120806214 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026311
 protein coding gene Chr4:105984935-105987035 (-)
CAST/EiJ MGP_CASTEiJ_G0027731
 protein coding gene Chr4:113055647-113065605 (-)
CBA/J MGP_CBAJ_G0028264
 protein coding gene Chr4:123993706-124003652 (-)
DBA/2J MGP_DBA2J_G0028412
 protein coding gene Chr4:112515178-112525115 (-)
FVB/NJ MGP_FVBNJ_G0028380
 protein coding gene Chr4:110986433-110996440 (-)
LP/J MGP_LPJ_G0028515
 protein coding gene Chr4:116486200-116496132 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028407
 protein coding gene Chr4:129102966-129113900 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029063
 protein coding gene Chr4:115417836-115427771 (-)
PWK/PhJ MGP_PWKPhJ_G0027458
 protein coding gene Chr4:109300807-109310864 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027283
 protein coding gene Chr4:111701021-111710975 (-)
WSB/EiJ MGP_WSBEiJ_G0027812
 protein coding gene Chr4:115253615-115263579 (-)



Homology
more
  • Human Ortholog
    CYP4A11, cytochrome P450 family 4 subfamily A member 11
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYP4A11, cytochrome P450 family 4 subfamily A member 11
  • Synonyms
    CP4Y, CYP4A2, CYP4AII, CYPIVA11
  • Links
    NCBI Gene ID: 1579
    neXtProt AC: NX_Q02928
    UniProt: Q02928

  • Chr Location
    1p33; chr1:46929177-46941484 (-)  GRCh38
  • Human Ortholog
    CYP4A22, cytochrome P450 family 4 subfamily A member 22
  • Links
    NCBI Gene ID: 284541
    neXtProt AC: NX_Q5TCH4
    UniProt: Q5TCH4

  • Chr Location
    1p33; chr1:47137435-47149727 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CYP4A11 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for disruption of this gene display high blood pressure. Blood pressure is elevated in females as well to levels comparable to normotensive males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    777
  • Tissues
    36
  • cDNA Data
    8
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028715 Ensembl Gene Model | MGI Sequence Detail 9943 C57BL/6J ±  kb
    transcript ENSMUST00000030487 Ensembl | MGI Sequence Detail 2496 Not Applicable  
    polypeptide ENSMUSP00000030487 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 8
      cDNA 8
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2140223
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:42094 Heng YM, et al., A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Biochem J. 1997 Aug 1;325(Pt 3):741-9
    • Latest
      J:272457 Gilani A, et al., High-fat diet-induced obesity and insulin resistance in CYP4a14(-/-) mice is mediated by 20-HETE. Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R934-R944
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory