Lasp1 MGI Mouse Gene Detail - MGI:109656

Symbol

Lasp1
Name

LIM and SH3 protein 1
Synonyms

Def-4, SH3P6

Feature Type

protein coding gene
IDs

MGI:109656
NCBI Gene: 16796
Alliance

gene page
Transcription Start Sites

26 TSS

Sequence Map

Chr11:97689826-97729590 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 61.10 cM, cytoband C-D
Mapping Data

5 experiments

SNPs within 2kb

1127 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109656	protein coding gene	Chr11:97689748-97729591 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019042	protein coding gene	Chr11:100274982-100317937 (+)
A/J	MGP_AJ_G0019010	protein coding gene	Chr11:96126879-96167489 (+)
AKR/J	MGP_AKRJ_G0018980	protein coding gene	Chr11:99111643-99151755 (+)
BALB/cJ	MGP_BALBcJ_G0018983	protein coding gene	Chr11:96627100-96666814 (+)
C3H/HeJ	MGP_C3HHeJ_G0018797	protein coding gene	Chr11:99234976-99276825 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019436	protein coding gene	Chr11:103364235-103406073 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017067	protein coding gene	Chr11:93581397-93621733 (+)
CAST/EiJ	MGP_CASTEiJ_G0018351	protein coding gene	Chr11:100100285-100138369 (+)
CBA/J	MGP_CBAJ_G0018768	protein coding gene	Chr11:107647703-107690217 (+)
DBA/2J	MGP_DBA2J_G0018876	protein coding gene	Chr11:95682449-95722517 (+)
FVB/NJ	MGP_FVBNJ_G0018865	protein coding gene	Chr11:95175280-95216525 (+)
LP/J	MGP_LPJ_G0018946	protein coding gene	Chr11:100771022-100813074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018892	protein coding gene	Chr11:107462007-107502689 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019476	protein coding gene	Chr11:99419586-99460456 (+)
PWK/PhJ	MGP_PWKPhJ_G0018123	protein coding gene	Chr11:96665012-96706360 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017913	protein coding gene	Chr11:99135674-99180554 (+)
WSB/EiJ	MGP_WSBEiJ_G0018401	protein coding gene	Chr11:99316480-99360033 (+)

Human Ortholog

LASP1, LIM and SH3 protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LASP1, LIM and SH3 protein 1
Synonyms

Lasp-1, MLN50
Links

HGNC:6513

NCBI Gene ID: 3927

neXtProt AC: NX_Q14847

UniProt: Q14847
Chr Location

17q12; chr17:38869859-38921770 (+) GRCh38

MGI Vertebrate Homology

Lasp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LASP1
Gene Tree

Lasp1

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Phenotype Summary

23 phenotypes from 2 alleles in 4 genetic backgrounds
4 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

215
Chemically induced (ENU)

1
Endonuclease-mediated

2
Gene trapped

208
Targeted

3
Transgenic

1
Genomic Mutations

1 involving Lasp1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

170 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced histamine-stimulated gastric acid secretion and enlarged heart and testes on a mixed background. Mice homozygous for a transgene insertion exhibit abnormal tail vertebrae with scoliosis, transient spina bifida occulta, and a bent tail.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

823
Tissues

96
cDNA Data

18
Literature Summary

15

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lasp1

ZFIN lasp1

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All Sequences

114
RefSeq

6
UniProt

14
CCDS

CCDS25332.1

Ensembl

ENSMUSG00000038366 (Evidence)
NCBI Gene

16796

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038366	Ensembl Gene Model \| MGI Sequence Detail	39765	C57BL/6J	± kb
transcript	ENSMUST00000043843	Ensembl \| MGI Sequence Detail	3540	Not Applicable
polypeptide	ENSMUSP00000042123	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

14 Sequences
Protein Ontology

PR:000009676 LIM and SH3 domain protein 1

(term hierarchy)
InterPro Domains

IPR035630 Lasp1, SH3 domain

IPR051759 LIM and SH3 domain-containing protein

IPR000900 Nebulin repeat

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR001781 Zinc finger, LIM-type
GlyGen

Q61792 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 21

cDNA 19

Primer pair 2

Microarray probesets 8

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MGD-MRK-39655, MGI:2143983, MGI:2429540

Summaries

All 63

Developmental Gene Expression 15

Gene Ontology 8

Phenotypes 22
Earliest

J:35786 Sparks AB, et al., Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. Nat Biotechnol. 1996 Jun;14(6):741-4
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lasp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104660	Chr11:97689821-97689847 (+)	8 bp
Tssr104661	Chr11:97690150-97690161 (+)	330 bp
Tssr104662	Chr11:97690216-97690227 (+)	396 bp
Tssr104663	Chr11:97690400-97690407 (+)	578 bp
Tssr104664	Chr11:97690412-97690423 (+)	592 bp
Tssr104665	Chr11:97690434-97690445 (+)	614 bp
Tssr104666	Chr11:97690453-97690473 (+)	637 bp
Tssr104667	Chr11:97690487-97690535 (+)	685 bp
Tssr104668	Chr11:97690586-97690597 (+)	766 bp
Tssr104669	Chr11:97690598-97690607 (+)	777 bp
Tssr104670	Chr11:97692743-97692781 (+)	2,936 bp
Tssr104671	Chr11:97697128-97697167 (+)	7,322 bp
Tssr104672	Chr11:97697424-97697446 (+)	7,609 bp
Tssr104673	Chr11:97697547-97697597 (+)	7,746 bp
Tssr104674	Chr11:97697637-97697641 (+)	7,813 bp
Tssr104675	Chr11:97706417-97706424 (+)	16,595 bp
Tssr104676	Chr11:97706465-97706476 (+)	16,645 bp
Tssr104677	Chr11:97706479-97706493 (+)	16,660 bp
Tssr104678	Chr11:97706551-97706562 (+)	16,731 bp
Tssr104679	Chr11:97716385-97716407 (+)	26,570 bp
Tssr104680	Chr11:97720958-97720969 (+)	31,138 bp
Tssr104681	Chr11:97724113-97724117 (+)	34,289 bp
Tssr104682	Chr11:97727179-97727194 (+)	37,361 bp
Tssr104683	Chr11:97728932-97728945 (+)	39,113 bp
Tssr104684	Chr11:97728957-97728972 (+)	39,139 bp
Tssr104685	Chr11:97729238-97729251 (+)	39,419 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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